Ferrandina Gabriella, Salutari Vanda, Testa Antonia, Zannoni Gian Franco, Petrillo Marco, Scambia Giovanni
Gynecologic Oncology Unit, Catholic University, L.go Gemelli 8, 00168, Rome, Italy.
BMC Cancer. 2006 Jun 27;6:169. doi: 10.1186/1471-2407-6-169.
The occurrence of skeletal muscle metastases is a very rare event. Only two cases of late skeletal muscle recurrence from cervical cancer have been documented until now.
A 38-year old patient, submitted to radical hysterectomy and pelvic lymphadenectomy for a squamous FIGO stage IB1 cervical carcinoma, presented after 76 months with a palpable, and painless swelling on the left hemithorax. MRI showed a nodule located in the context of the intercostal muscles. Pathology revealed the presence of metastasis of squamous cell carcinoma of similar morphology as the primary. On the basis of FDG-PET findings, which excluded other sites of disease, surgical excision of the lesion was performed. The patient was triaged to chemotherapy plus external radiotherapy.
A case of skeletal muscle recurrence from cervical cancer after a very long interval from primary diagnosis is reported. Muscular pain or weakness, or just a palpable mass in a patient with a history of cancer has always to raise the suspicion of muscle metastasis.
骨骼肌转移的发生是非常罕见的事件。截至目前，仅有两例宫颈癌晚期骨骼肌复发的病例被记录。
一名38岁女性患者，因国际妇产科联盟（FIGO）分期为IB1期的鳞状宫颈癌接受了根治性子宫切除术和盆腔淋巴结清扫术，76个月后左侧半胸出现可触及的无痛性肿块。磁共振成像（MRI）显示一个位于肋间肌的结节。病理检查显示存在形态与原发肿瘤相似的鳞状细胞癌转移灶。基于氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）结果排除了其他疾病部位后，对该病变进行了手术切除。患者接受了化疗加体外放疗。
报告了一例宫颈癌在初次诊断后很长时间出现骨骼肌复发的病例。对于有癌症病史的患者，肌肉疼痛或无力，或仅一个可触及的肿块，始终要怀疑肌肉转移。
