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子宫颈鳞状细胞癌骨骼肌转移:一例病例报告及文献复习

Recurrence in skeletal muscle from squamous cell carcinoma of the uterine cervix: a case report and review of the literature.

作者信息

Ferrandina Gabriella, Salutari Vanda, Testa Antonia, Zannoni Gian Franco, Petrillo Marco, Scambia Giovanni

机构信息

Gynecologic Oncology Unit, Catholic University, L.go Gemelli 8, 00168, Rome, Italy.

出版信息

BMC Cancer. 2006 Jun 27;6:169. doi: 10.1186/1471-2407-6-169.

Abstract

BACKGROUND

The occurrence of skeletal muscle metastases is a very rare event. Only two cases of late skeletal muscle recurrence from cervical cancer have been documented until now.

CASE PRESENTATION

A 38-year old patient, submitted to radical hysterectomy and pelvic lymphadenectomy for a squamous FIGO stage IB1 cervical carcinoma, presented after 76 months with a palpable, and painless swelling on the left hemithorax. MRI showed a nodule located in the context of the intercostal muscles. Pathology revealed the presence of metastasis of squamous cell carcinoma of similar morphology as the primary. On the basis of FDG-PET findings, which excluded other sites of disease, surgical excision of the lesion was performed. The patient was triaged to chemotherapy plus external radiotherapy.

CONCLUSION

A case of skeletal muscle recurrence from cervical cancer after a very long interval from primary diagnosis is reported. Muscular pain or weakness, or just a palpable mass in a patient with a history of cancer has always to raise the suspicion of muscle metastasis.

摘要

背景

骨骼肌转移的发生是非常罕见的事件。截至目前,仅有两例宫颈癌晚期骨骼肌复发的病例被记录。

病例报告

一名38岁女性患者,因国际妇产科联盟(FIGO)分期为IB1期的鳞状宫颈癌接受了根治性子宫切除术和盆腔淋巴结清扫术,76个月后左侧半胸出现可触及的无痛性肿块。磁共振成像(MRI)显示一个位于肋间肌的结节。病理检查显示存在形态与原发肿瘤相似的鳞状细胞癌转移灶。基于氟代脱氧葡萄糖正电子发射断层扫描(FDG-PET)结果排除了其他疾病部位后,对该病变进行了手术切除。患者接受了化疗加体外放疗。

结论

报告了一例宫颈癌在初次诊断后很长时间出现骨骼肌复发的病例。对于有癌症病史的患者,肌肉疼痛或无力,或仅一个可触及的肿块,始终要怀疑肌肉转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1411/1523362/de6aa28e6b1f/1471-2407-6-169-1.jpg

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