评估早产与从下生殖道分离出的各种微生物之间的关系。
Assessing the relationship between preterm delivery and various microorganisms recovered from the lower genital tract.
作者信息
Edwards Rodney K, Ferguson Ronald J, Reyes Leticia, Brown Mary, Theriaque Douglas W, Duff Patrick
机构信息
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610-0294, USA.
出版信息
J Matern Fetal Neonatal Med. 2006 Jun;19(6):357-63. doi: 10.1080/00207170600712071.
OBJECTIVE
To determine if the likelihood of preterm delivery is more dependent on the specific organisms present in the vagina than on the presence of bacterial vaginosis.
METHODS
We evaluated the vaginal fluid of a prospective cohort of women at 23-32 weeks of gestation with signs and symptoms of preterm labor and intact membranes. Forward stepwise logistic regression models were used to evaluate the relationship between preterm delivery and the presence of anaerobic bacteria, Gardnerella, ureaplasmas and mycoplasmas, and sialidase.
RESULTS
The cohort included 137 women, and complete delivery information was available for 134 of them. The rate of preterm delivery was 28% (37 of 134). Mycoplasma genitalium independently was associated with spontaneous preterm delivery (OR 3.48; 95% CI 1.41, 8.57). After controlling for this factor, none of the other variables were significantly prognostic for spontaneous preterm delivery (residual overall p = 0.19).
CONCLUSION
The presence of Mycoplasma genitalium in the vagina of pregnant women is an independent risk factor for spontaneous preterm delivery.
目的
确定早产的可能性是否更多地取决于阴道中存在的特定微生物，而非细菌性阴道病的存在。
方法
我们评估了一组前瞻性队列中妊娠23 - 32周、有早产迹象和症状且胎膜完整的女性的阴道分泌物。采用向前逐步逻辑回归模型来评估早产与厌氧菌、加德纳菌、脲原体、支原体以及唾液酸酶存在之间的关系。
结果
该队列包括137名女性，其中134名有完整的分娩信息。早产率为28%（134名中的37名）。生殖支原体与自发性早产独立相关（比值比3.48；95%置信区间1.41, 8.57）。在控制该因素后，其他变量均对自发性早产无显著预后意义（剩余总体p = 0.19）。
结论
孕妇阴道中存在生殖支原体是自发性早产的一个独立危险因素。
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