头孢洛林及其他β-内酰胺类药物对来自美国的肺炎链球菌临床分离株的活性，这些分离株在青霉素结合蛋白PBP 1a、PBP 2b和PBP 2x中存在特定替换。
Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.
作者信息
Davies Todd A, Shang Wenchi, Bush Karen
机构信息
Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ 08869, USA.
出版信息
Antimicrob Agents Chemother. 2006 Jul;50(7):2530-2. doi: 10.1128/AAC.00238-06.
Abstract
The activities of ceftobiprole and other beta-lactams were examined with 30 Streptococcus pneumoniae isolates containing multiple pbp1a, pbp2b, and pbp2x mutations. The highest ceftobiprole MIC was 1 microg/ml, while the comparator MICs were 16 to 64 microg/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 microg/ml (ceftobiprole) and 4 microg/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.
摘要
使用30株含有多个pbp1a、pbp2b和pbp2x突变的肺炎链球菌分离株检测了头孢比普和其他β-内酰胺类药物的活性。头孢比普的最高最低抑菌浓度（MIC）为1微克/毫升，而对照药物的MIC为16至64微克/毫升。在一株对青霉素和头孢曲松耐药的分离株中，青霉素结合蛋白2x的50%抑制浓度分别为0.5微克/毫升（头孢比普）和4微克/毫升（头孢曲松）。
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