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两对同卵双胞胎,其中一对为女性向男性的变性者,另一对与之不同。

Two monozygotic twin pairs discordant for female-to-male transsexualism.

作者信息

Segal Nancy L

机构信息

Department of Psychology, California State University, Fullerton, California 92834, USA.

出版信息

Arch Sex Behav. 2006 Jun;35(3):347-58. doi: 10.1007/s10508-006-9037-3. Epub 2006 Jun 27.

DOI:10.1007/s10508-006-9037-3
PMID:16802182
Abstract

Two monozygotic female twin pairs discordant for transsexualism are described. These reports double the number of such case studies in the current scientific literature. Interviews with the twins and their families indicated that unusual medical and life history factors did not play causal roles. However, inspection of medical records for one transsexual twin suggested that some early life experiences may have exacerbated tendencies toward male gender identification. In both pairs, the twins' gender identity differences emerged early, consistent with, but not proof of, co-twin differences in prenatal hormonal influences. The identification of additional discordant MZ female twin pairs can advance biological and psychological understanding of transsexualism. Suggestions for future research, based upon findings from these two twin pairs and from studies of female-to-male transsexuals, are provided.

摘要

本文描述了两对同卵双胞胎女性,她们患易性癖的情况不一致。这些报告使当前科学文献中此类案例研究的数量增加了一倍。对双胞胎及其家人的访谈表明,异常的医学和生活史因素并未起到因果作用。然而,对一名易性癖双胞胎的病历检查表明,一些早年经历可能加剧了男性性别认同倾向。在这两对双胞胎中,双胞胎的性别认同差异很早就出现了,这与产前激素影响下的双胞胎差异相符,但并非其证据。识别更多不一致的同卵双胞胎女性对增进对易性癖的生物学和心理学理解具有推动作用。基于这两对双胞胎以及对女变男易性癖者的研究结果,提供了对未来研究的建议。

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Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.深度测序揭示了患有不一致精神疾病的同卵双胞胎之间体细胞镶嵌突变的差异。
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