Rolland A, Fleurentin J, Lanhers M C, Younos C, Misslin R, Mortier F, Pelt J M
Laboratoire de Pharmacognosie, Université de Metz, France.
Planta Med. 1991 Jun;57(3):212-6. doi: 10.1055/s-2006-960076.
Eschsholzia californica Cham. is a traditional medicinal plant of the Indians used by the rural population of California for its analgesic and sedative properties. Our study on the aqueous extract shows that this plant reduced the behavioural parameters measured in a familiar environment test in mice (novelty preference, locomotion and rearings in two compartments test) at doses above 100 mg/kg and in non-familiar environment tests (staircase test) at doses above 200 mg/kg. This finding validates its traditional sedative properties confirmed by the sleeping induction at doses above 100 mg/kg. Furthermore, when administered at a dose a of 25 mg/kg, E. californica appeared to also have an anxiolytic action since it produced an increase of the number of steps climbed by mice in the staircase test (anticonflict effect) and that of the time spent by animals in the lit box when they were confronted with the light/dark choice situation. Before evaluation of the behavioural effects, it was verified that our aqueous extract did not induce any toxic effect when administered i.p. and p.o.
加州罂粟是印第安人的传统药用植物，加利福尼亚农村人口因其具有止痛和镇静特性而使用。我们对水提取物的研究表明，该植物在剂量高于100mg/kg时能降低在熟悉环境试验（新异偏好、两隔室试验中的运动和竖毛行为）中测量的小鼠行为参数，在剂量高于200mg/kg时能降低在非熟悉环境试验（阶梯试验）中的行为参数。这一发现证实了其传统的镇静特性，在剂量高于100mg/kg时可诱导睡眠。此外，当以25mg/kg的剂量给药时，加州罂粟似乎还具有抗焦虑作用，因为它在阶梯试验中使小鼠攀爬的步数增加（抗冲突效应），并且在动物面对明/暗选择情境时，使它们在亮箱中停留的时间增加。在评估行为效应之前，已证实我们的水提取物经腹腔注射和口服给药时不会诱导任何毒性作用。
