Department of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Planta Med. 2022 Oct;88(12):1036-1046. doi: 10.1055/a-1628-8132. Epub 2021 Oct 8.
Pregnancy is a critical period for medical care, during which the well-being of woman and fetus must be considered. This is particularly relevant in managing non-psychotic mental disorders since treatment with central nervous system-active drugs and untreated NMDs may have negative effects. Some well-known herbal preparations (phytopharmaceuticals), including St. John's wort, California poppy, valerian, lavender, and hops, possess antidepressant, sedative, anxiolytic, or antidepressant properties and could be used to treat mental diseases such as depression, restlessness, and anxiety in pregnancy. Our goal was to assess their safety , focusing on cytotoxicity, induction of apoptosis, genotoxicity, and effects on metabolic properties and differentiation in cells widely used as a placental cell model (BeWo b30 placenta choriocarcinoma cells). The lavender essential oil was inconspicuous in all experiments and showed no detrimental effects. At low-to-high concentrations, no extract markedly affected the chosen safety parameters. At an artificially high concentration of 100 µg/mL, extracts from St. John's wort, California poppy, valerian, and hops had minimal cytotoxic effects. None of the extracts resulted in genotoxic effects or altered glucose consumption or lactate production, nor did they induce or inhibit BeWo b30 cell differentiation. This study suggests that all tested preparations from St. John's wort, California poppy, valerian, lavender, and hops, in concentrations up to 30 µg/mL, do not possess any cytotoxic or genotoxic potential and do not compromise placental cell viability, metabolic activity, and differentiation. Empirical and clinical studies during pregnancy are needed to support these data.
妊娠是医疗保健的关键时期，必须考虑妇女和胎儿的健康。这在管理非精神病性精神障碍方面尤为重要，因为中枢神经系统活性药物的治疗和未经治疗的 NMD 可能会产生负面影响。一些著名的草药制剂（植物药），包括贯叶连翘、加利福尼亚罂粟、缬草、薰衣草和啤酒花，具有抗抑郁、镇静、抗焦虑或抗抑郁作用，可用于治疗怀孕期间的精神疾病，如抑郁症、不安和焦虑。我们的目标是评估它们的安全性，重点关注细胞毒性、细胞凋亡诱导、遗传毒性以及对代谢特性和细胞分化的影响，这些细胞广泛用作胎盘细胞模型（BeWo b30 胎盘绒毛膜癌细胞）。薰衣草精油在所有实验中都不明显，没有产生有害影响。在低至高浓度下，没有一种提取物显著影响所选的安全参数。在人为的高浓度 100µg/mL 下，贯叶连翘、加利福尼亚罂粟、缬草和啤酒花的提取物具有最小的细胞毒性作用。没有一种提取物产生遗传毒性作用或改变葡萄糖消耗或乳酸产生，也没有诱导或抑制 BeWo b30 细胞分化。这项研究表明，在高达 30µg/mL 的浓度下，所有测试的贯叶连翘、加利福尼亚罂粟、缬草、薰衣草和啤酒花制剂都不具有任何细胞毒性或遗传毒性潜力，也不会损害胎盘细胞的活力、代谢活性和分化。需要进行妊娠期间的实证和临床研究来支持这些数据。
