Soulimani R, Fleurentin J, Mortier F, Misslin R, Derrieu G, Pelt J M
Laboratoire de Pharmacognosie, Université de Metz, France.
Planta Med. 1991 Apr;57(2):105-9. doi: 10.1055/s-2006-960042.
A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (staircase test) and in a familiar environment test (two compartment test). With high doses, a peripheral analgesic activity was obtained by reducing the acetic acid-induced pain (writhing test); moreover, the plant extract induced the sleep in mice after treatment with an infrahypnotic dose of pentobarbital and potentialised the sleep induced by a hypnotic dose of pentobarbital.
已对唇形科植物蜜蜂花（Melissa officinalis L.）的冻干水醇提取物在小鼠中的行为效应进行了评估。根据蜜蜂花的传统用途，在陌生环境试验（阶梯试验）和熟悉环境试验（两室试验）中测量的行为参数降低，证实了低剂量具有镇静特性。高剂量时，通过减少醋酸诱导的疼痛（扭体试验）获得外周镇痛活性；此外，该植物提取物在用低于催眠剂量的戊巴比妥处理后可诱导小鼠睡眠，并增强催眠剂量戊巴比妥诱导的睡眠。
