N-乙酰天门冬氨酸的生理作用：对髓鞘形成的贡献。 - Suppr

Physiological role of N-acetylaspartate: contribution to myelinogenesis.

作者信息

Ledeen Robert W, Wang Jianfeng, Wu Gusheng, Lu Zi-Hua, Chakraborty Goutam, Meyenhofer Markus, Tyring Stephen K, Matalon Reuben

机构信息

Dept. Neurology & Neurosciences, New Jersey Medical School, UMDNJ, 185 So. Orange Ave., Newark, NJ 07103, USA.

出版信息

Adv Exp Med Biol. 2006;576:131-43; discussion 361-3. doi: 10.1007/0-387-30172-0_9.

DOI:10.1007/0-387-30172-0_9

PMID:16802709

Abstract

摘要

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Physiological role of N-acetylaspartate: contribution to myelinogenesis.N-乙酰天门冬氨酸的生理作用：对髓鞘形成的贡献。

Adv Exp Med Biol. 2006;576:131-43; discussion 361-3. doi: 10.1007/0-387-30172-0_9.

Defective myelin lipid synthesis as a pathogenic mechanism of Canavan disease.髓鞘脂质合成缺陷作为卡纳万病的致病机制

Adv Exp Med Biol. 2006;576:145-63; discussion 361-3. doi: 10.1007/0-387-30172-0_10.

Preface: a brief review of N-acetylaspartate.前言：N-乙酰天门冬氨酸简要综述

Adv Exp Med Biol. 2006;576:vii-xiii.

N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain.N-乙酰天门冬氨酸合成酶在脑微粒体和线粒体中呈双峰表达。

Brain Res Mol Brain Res. 2004 Mar 17;122(1):71-8. doi: 10.1016/j.molbrainres.2003.12.002.

Localisation of N-acetylaspartate in oligodendrocytes/myelin.N-乙酰天门冬氨酸在少突胶质细胞/髓鞘中的定位。

Brain Struct Funct. 2015 Mar;220(2):899-917. doi: 10.1007/s00429-013-0691-7. Epub 2013 Dec 31.

NAA synthesis and functional roles.N-乙酰天门冬氨酸（NAA）的合成及功能作用

Adv Exp Med Biol. 2006;576:49-66; discussion 361-3. doi: 10.1007/0-387-30172-0_4.

Dietary treatment proposed for Canavan's disease.针对卡纳万病提出的饮食疗法。

Lancet Neurol. 2005 May;4(5):273. doi: 10.1016/s1474-4422(05)70060-0.

Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate.SHATI/NAT8L的缺失会降低大脑中N-乙酰天门冬氨酸的含量，并引发行为缺陷，而给予N-乙酰天门冬氨酸可改善这些缺陷。

Eur Neuropsychopharmacol. 2015 Nov;25(11):2108-17. doi: 10.1016/j.euroneuro.2015.08.003. Epub 2015 Aug 12.

Bimodal occurrence of aspartoacylase in myelin and cytosol of brain.天冬氨酸酰基转移酶在脑髓鞘和细胞质中的双峰分布。

J Neurochem. 2007 Apr;101(2):448-57. doi: 10.1111/j.1471-4159.2006.04380.x. Epub 2007 Jan 24.

N-acetylaspartate metabolism in neural cells.神经细胞中的N-乙酰天门冬氨酸代谢

Adv Exp Med Biol. 2006;576:27-47; discussion 361-3. doi: 10.1007/0-387-30172-0_3.

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Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo.线粒体天冬氨酸-谷氨酸载体 1 缺乏导致体外和体内少突胶质前体细胞增殖缺陷。

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The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition.神经元代谢物NAA调节少突胶质细胞中的组蛋白H3甲基化和髓磷脂脂质组成。

Exp Brain Res. 2017 Jan;235(1):279-292. doi: 10.1007/s00221-016-4789-z. Epub 2016 Oct 5.

N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time.N-乙酰天门冬氨酸合成酶缺乏症纠正了卡纳万病小鼠模型中的髓鞘表型，但不影响存活时间。

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Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia.精神分裂症患者死后前扣带回皮质中突触和线粒体密度降低。

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The mitochondrial aspartate/glutamate carrier isoform 1 gene expression is regulated by CREB in neuronal cells.线粒体天冬氨酸/谷氨酸载体亚型1基因的表达在神经元细胞中受CREB调控。

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Physiological role of N-acetylaspartate: contribution to myelinogenesis.

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