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Atenolol, exaprolol and mast cell membranes.

作者信息

Pecivová J, Drábiková K, Jancinová V, Petríková M, Nosál R

机构信息

Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

出版信息

Agents Actions. 1991 May;33(1-2):41-3. doi: 10.1007/BF01993122.

DOI:10.1007/BF01993122
PMID:1680276
Abstract

Lipophilic exaprolol and hydrophilic atenolol differ in their interaction with mast cell membranes. Exaprolol, as compared with atenolol, significantly decreased 32P incorporation into, but increased arachidonic acid liberation from, membrane phospholipids. Moreover, exaprolol significantly decreased phosphate incorporation in compound 48/80 and ConA-PS treated cells and decreased thromboxane formation in stimulated cells. On the other hand, atenolol decreased significantly only arachidonate liberation from stimulated mast cells. These results corroborate to some extent the effect of exaprolol and atenolol on histamine liberation which correlates with their membrane perturbing properties.

摘要

相似文献

1
Atenolol, exaprolol and mast cell membranes.
Agents Actions. 1991 May;33(1-2):41-3. doi: 10.1007/BF01993122.
2
The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.β-肾上腺素能受体阻断药物对伴刀豆球蛋白A刺激的离体肥大细胞中组胺释放、前列腺素合成及磷脂周转的影响
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3
Effect of beta-adrenoceptor blocking drugs on 32P incorporation into and arachidonic acid liberation from phospholipids in stimulated rat mast cells.β-肾上腺素能阻断药物对受刺激大鼠肥大细胞中磷脂掺入32P及花生四烯酸从磷脂释放的影响。
Agents Actions. 1989 Apr;27(1-2):29-32. doi: 10.1007/BF02222189.
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Effect of chloroquine on isolated mast cells.氯喹对分离的肥大细胞的作用。
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5
[The effect of adrenergic beta receptor blockers on phospholipid metabolism in mast cells].[肾上腺素能β受体阻滞剂对肥大细胞磷脂代谢的影响]
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6
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J Physiol Pharmacol. 1994 Sep;45(3):377-86.
7
On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells.关于32P掺入磷脂与β-肾上腺素能受体阻断药物与分离的肥大细胞结合之间的关系。
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Evidence for intracellular histamine liberation in isolated rat mast cells.离体大鼠肥大细胞内组胺释放的证据。
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Differential activation of membrane phospholipid turnover by compound 48/80 and ionophore A23187 in rat mast cells.化合物48/80和离子载体A23187对大鼠肥大细胞膜磷脂周转的差异性激活作用。
Arch Biochem Biophys. 1984 Jul;232(1):259-68. doi: 10.1016/0003-9861(84)90542-3.

本文引用的文献

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Comparisons of the interaction of propranolol and timolol with model and biological membrane systems.普萘洛尔和噻吗洛尔与模型及生物膜系统相互作用的比较。
Mol Pharmacol. 1983 Sep;24(2):259-69.
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Suppression by phospholipase A2 inhibitors of secretion of catecholamines from isolated adrenal medullary cells by suppression of cellular calcium uptake.磷脂酶A2抑制剂通过抑制细胞钙摄取来抑制离体肾上腺髓质细胞儿茶酚胺的分泌。
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Selectivity of beta-adrenoceptor agonists and antagonists in asthmatics.
β-肾上腺素能受体激动剂与拮抗剂在哮喘患者中的选择性
Eur J Respir Dis Suppl. 1982;120:1-53.
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Diacylglycerol lipase activity in human platelet intracellular and surface membranes. Some kinetic properties and fatty acid specificity.
FEBS Lett. 1985 Jan 21;180(1):95-101. doi: 10.1016/0014-5793(85)80239-8.
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On the relationship between incorporation of 32P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells.关于32P掺入磷脂与β-肾上腺素能受体阻断药物与分离的肥大细胞结合之间的关系。
Agents Actions. 1988 Apr;23(3-4):146-8. doi: 10.1007/BF02142524.
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Classification of beta-blocking agents by their inhibitory effects on phospholipase activity.根据β受体阻滞剂对磷脂酶活性的抑制作用进行分类。
Jpn Circ J. 1986 Mar;50(3):238-41. doi: 10.1253/jcj.50.238.
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Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells.
Agents Actions. 1989 Apr;27(1-2):36-8. doi: 10.1007/BF02222191.
8
The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A.β-肾上腺素能受体阻断药物对伴刀豆球蛋白A刺激的离体肥大细胞中组胺释放、前列腺素合成及磷脂周转的影响
Agents Actions. 1990 Apr;30(1-2):77-80. doi: 10.1007/BF01969003.
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Propranolol, chlorpromazine and platelet membrane: a fluorescence study of the drug-membrane interaction.
Thromb Res. 1979 Jan;14(1):15-22. doi: 10.1016/0049-3848(79)90020-3.
10
The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiestease on histamine release from isolated mast cells.β-肾上腺素能阻断药和磷酸二酯酶抑制剂对分离肥大细胞组胺释放的影响。
Agents Actions. 1977 Jul;7(2):231-6. doi: 10.1007/BF01969978.