[肾上腺素能β受体阻滞剂对肥大细胞磷脂代谢的影响]
[The effect of adrenergic beta receptor blockers on phospholipid metabolism in mast cells].
作者信息
Pecivová J, Drábiková K, Nosál' R
机构信息
Ustavu experimentálnej farmakológie CFV SAV, Bratislava.
出版信息
Bratisl Lek Listy. 1990 May;91(5):363-8.
The aim of this study was to determine whether beta adrenergic receptor blocking drugs exaprolol, metipranolol and propranolol effect the metabolism of phospholipids in isolated rat mast cells. The phospholipids were labelled by 3H-arachidonic acid (3H-AA) and 32P. Exaprolol, metipranolol and propranolol significantly modulated 32P incorporation into phospholipids of resting and 48/80 stimulated cells. Atenolol had no effect. Studies with 3H-AA Labelled mast cells showed an enhanced liberation of arachidonate related radioactivity on exaprolol and propranolol treatment. The results indicated that 3H-activity was lost mainly from phosphatidylethanolamine. Atenolol and metipranolol significantly decreased the 48/80 stimulated 3H-AA release.
本研究的目的是确定β-肾上腺素能受体阻断药物心得舒、甲心安和普萘洛尔是否会影响分离的大鼠肥大细胞中磷脂的代谢。磷脂用3H-花生四烯酸（3H-AA）和32P进行标记。心得舒、甲心安和普萘洛尔显著调节了32P掺入静息和经48/80刺激的细胞的磷脂中。阿替洛尔没有作用。对3H-AA标记的肥大细胞的研究表明，心得舒和普萘洛尔处理后，花生四烯酸盐相关放射性的释放增加。结果表明，3H活性主要从磷脂酰乙醇胺中丧失。阿替洛尔和甲心安显著降低了经48/80刺激后的3H-AA释放。
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