Pecivová J, Drábiková K, Nosál R
Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Agents Actions. 1989 Apr;27(1-2):29-32. doi: 10.1007/BF02222189.
The lipophilic beta-adrenoceptor blocking (BAB) drugs metipranolol, propranolol and exaprolol significantly decreased 48/80- and A23187-induced 32P incorporation into rat mast cell phospholipids. Exaprolol was the most active, followed by propranolol and metipranolol. Atenolol and metipranolol significantly decreased the 48/80-stimulated, and metipranolol and exaprolol the A23187-stimulated 3H-arachidonic acid liberation from isolated mast cells.
亲脂性β-肾上腺素受体阻断（BAB）药物美替洛尔、普萘洛尔和依沙洛尔显著降低了48/80和A23187诱导的32P掺入大鼠肥大细胞磷脂的量。依沙洛尔活性最强，其次是普萘洛尔和美替洛尔。阿替洛尔和美替洛尔显著降低了48/80刺激的肥大细胞中3H-花生四烯酸的释放，美替洛尔和依沙洛尔则显著降低了A23187刺激的肥大细胞中3H-花生四烯酸的释放。
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