Travers Cheryl A, Guttikonda Kamala, Norton Carol A, Lewis Peter R, Mollart Lyndall J, Wiley Veronica, Wilcken Bridget, Eastman Creswell J, Boyages Steven C
Central Coast Public Health Unit, Northern Sydney Central Coast Area Health Service, Gosford, NSW, Australia.
Med J Aust. 2006 Jun 19;184(12):617-20. doi: 10.5694/j.1326-5377.2006.tb00417.x.
To determine whether pregnant women and their newborns show evidence of iodine deficiency, and to examine the correlation between maternal urine iodine concentration (UIC) and newborn thyroid-stimulating hormone (TSH) level.
A cross-sectional study.
Hospital antenatal care services (March-May 2004) and private obstetrician clinics (June 2004) in the Central Coast area of New South Wales.
815 pregnant women (> or = 28 weeks' gestation) and 824 newborns.
World Health Organization/International Council for the Control of Iodine Deficiency Disorders criteria for assessing severity of iodine deficiency (recommended levels: < 20% of urine samples in a population with UIC < 50 microg/L; and < 3% of newborns with whole-blood TSH level > 5 mIU/L).
The median UIC for pregnant women was 85 microg/L, indicating mild iodine deficiency. Almost 17% of pregnant women had a UIC < 50 microg/L, and 18 newborns (2.2%) had TSH values > 5 mIU/L. There was no statistically significant linear correlation between neonatal whole-blood TSH level and maternal UIC (r = - 0.03; P = 0.4). Mothers with a UIC < 50 microg/L were 2.6 times (relative risk = 2.65; 95% CI, 1.49-4.73; P = 0.01) more likely to have a baby with a TSH level > 5 mIU/L.
The pregnant women surveyed were mildly iodine deficient. TSH values for their newborns were mostly within acceptable limits. Ongoing surveillance of the iodine status of NSW communities to establish trends over time is recommended.
确定孕妇及其新生儿是否有碘缺乏的迹象，并检查孕妇尿碘浓度（UIC）与新生儿促甲状腺激素（TSH）水平之间的相关性。
横断面研究。
新南威尔士州中部海岸地区的医院产前护理服务机构（2004年3月至5月）和私人产科诊所（2004年6月）。
815名孕妇（妊娠≥28周）和824名新生儿。
世界卫生组织/国际碘缺乏病控制理事会评估碘缺乏严重程度的标准（推荐水平：UIC＜50μg/L人群中尿样＜20%；全血TSH水平＞5mIU/L的新生儿＜3%）。
孕妇的UIC中位数为85μg/L，表明存在轻度碘缺乏。近17%的孕妇UIC＜50μg/L，18名新生儿（2.2%）TSH值＞5mIU/L。新生儿全血TSH水平与孕妇UIC之间无统计学显著线性相关性（r = -0.03；P = 0.4）。UIC＜50μg/L的母亲生出TSH水平＞5mIU/L婴儿的可能性高2.6倍（相对风险 = 2.65；95%可信区间，1.49 - 4.73；P = 0.01）。
接受调查的孕妇存在轻度碘缺乏。其新生儿的TSH值大多在可接受范围内。建议对新南威尔士州社区的碘状况进行持续监测，以确定随时间的变化趋势。
