Piña-Sánchez P, Hernández-Hernández D M, López-Romero R, Vázquez-Ortíz G, Pérez-Plasencia C, Lizano-Soberón M, González-Sánchez J L, Cruz-Talonia F, Salcedo M
Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, Centro Médico Nacional Siglo XXI-IMSS, Av. Cuauhtémoc 330, Col Doctores, México DF 06720, México.
Int J Gynecol Cancer. 2006 May-Jun;16(3):1041-7. doi: 10.1111/j.1525-1438.2006.00458.x.
Cervical cancer (CC) is the most common in Mexican female population. The human papillomavirus (HPV) 16 and 18 frequencies in worldwide may be different due to geographical distribution. We analyzed the prevalence of HPV types and determinated their association in cervical lesion in a Mexican population. One hundred fifty-nine normal cervical smears, 95 low-grade squamous intraepithelial lesions (LGSIL), 59 high-grade squamous intraepithelial lesions (HGSIL), and 108 CC samples of the patients were collected. HPV types were determined by sequencing. We detected 11 high-risk types, four low-risk types, three not determinated, and two probably high risk. HPV were present in 12%, 57%, 88%, and 92% from normal, LGSIL, HGSIL, and CC samples, respectively. HPV 16 was the most common in all cervical lesions (71.6% in CC). HPV 58 was present in 18.6% of HGSIL, and the HPV 18 in 4.6% of CC. The 76% of all detected viruses belong to A9 species branch. Control women showed high percentage of HPV high-risk infection, suggesting that this is a high-risk group. High frequency of HPV 16 compared with a low incidence of HPV 18 was observed. HPV 58 is frequently detected in HGSIL but low frequency is found in CC. These findings might be considered for HPV screening.
宫颈癌（CC）在墨西哥女性人群中最为常见。由于地理分布的原因，全球范围内人乳头瘤病毒（HPV）16型和18型的感染频率可能有所不同。我们分析了墨西哥人群中HPV各型别的流行情况，并确定了它们与宫颈病变的关联。收集了159例正常宫颈涂片、95例低级别鳞状上皮内病变（LGSIL）、59例高级别鳞状上皮内病变（HGSIL）以及108例宫颈癌患者的样本。通过测序确定HPV型别。我们检测到11种高危型、4种低危型、3种未确定型以及2种可能的高危型。HPV分别在正常、LGSIL、HGSIL和宫颈癌样本中的检出率为12%、57%、88%和92%。HPV 16型在所有宫颈病变中最为常见（在宫颈癌中占71.6%）。HPV 58型在18.6%的HGSIL中出现，HPV 18型在4.6%的宫颈癌中出现。所有检测到的病毒中有76%属于A9种系分支。对照女性显示出较高比例的HPV高危感染，表明这是一个高危群体。观察到HPV 16型的高频率与HPV 18型的低发病率。HPV 58型在HGSIL中经常被检测到，但在宫颈癌中频率较低。这些发现可能对HPV筛查具有参考意义。
