口服克拉霉素对正常受试者及胆结石患者胆囊运动的影响。

Effect of oral clarithromycin on gall-bladder motility in normal subjects and those with gall-stones.

作者信息

Sengupta S, Modak P, McCauley N, O'Donnell L J D

机构信息

Department of Medicine and Gastroenterology, Mayo General Hospital, Castlebar, Ireland.

出版信息

Aliment Pharmacol Ther. 2006 Jul 1;24(1):95-9. doi: 10.1111/j.1365-2036.2006.02962.x.

DOI:10.1111/j.1365-2036.2006.02962.x

PMID:16803607

Abstract

BACKGROUND

Motilin receptor stimulation with erythromycin has been shown to have a prokinetic effect on gall-bladder motility in human beings.

AIM

To find out whether oral clarithromycin has similar prokinetic activity to erythromycin on fasting and postprandial gall-bladder emptying in normal humans and those with gall-stone disease.

METHODS

In a blinded two-way crossover study clarithromycin 500 mg and a placebo were administered to 10 normal subjects and 10 subjects with gall-stone disease. Gall-bladder volumes were assessed in the fasting and postprandial state.

RESULTS

Fasting volumes were significantly less following clarithromycin administration in both normal subjects and subjects with gall-stones compared with placebo (12.1 +/- 1.8 mL vs. 17.8 +/- 2.0 mL, P < 0.05 and 16.7 +/- 2 mL vs. 26.8 +/- 7.2 mL, P < 0.02, mean +/- S.E.M). Postprandial volumes were also significantly less following clarithromycin administration. Ejection fraction significantly increased following clarithromycin in both normal subjects (66 +/- 5.8% vs. 37 +/- 5.9%, P = 0.02) and subjects with gall-stones (45 +/- 3.2 vs. 20 +/- 1.6%, P < 0.02).

CONCLUSION

Clarithromycin enhances both fasting and postprandial gall-bladder contraction in normal humans and also in those with gall-stone disease.

摘要

背景

已证明用红霉素刺激胃动素受体对人类胆囊运动有促动力作用。

目的

探究口服克拉霉素在正常人和患有胆结石疾病的人群中，对空腹和餐后胆囊排空是否具有与红霉素相似的促动力活性。

方法

在一项双盲双向交叉研究中，对10名正常受试者和10名患有胆结石疾病的受试者给予500毫克克拉霉素和安慰剂。在空腹和餐后状态下评估胆囊容积。

结果

与安慰剂相比，正常受试者和患有胆结石的受试者在服用克拉霉素后空腹胆囊容积均显著减小（分别为12.1±1.8毫升对17.8±2.0毫升，P<0.05；16.7±2毫升对26.8±7.2毫升，P<0.02，均值±标准误）。服用克拉霉素后餐后胆囊容积也显著减小。正常受试者和患有胆结石的受试者在服用克拉霉素后射血分数均显著增加（分别为66±5.8%对37±5.9%，P=0.02；45±3.2对20±1.6%，P<0.02）。