Zhang E T, Mikkelsen J D, Møller M
Institute of Medical Anatomy, Panum Institute, University of Copenhagen, Denmark.
Cell Tissue Res. 1991 Jul;265(1):63-71. doi: 10.1007/BF00318140.
The distribution of tyrosine hydroxylase (TH)- and neuropeptide Y (NPY)-immunoreactive(IR) nerve fibers in the pineal complex was investigated in untreated rats and rats following bilateral removal of the superior cervical ganglia. In normal animals, a large number of TH- and NPY-IR nerve fibers were present in the pineal capsule, the perivascular spaces, and intraparenchymally between the pinealocytes throughout the superficial pineal and deep pineal gland. A small number of TH-IR and NPY-IR nerve fibers were found in the posterior and habenular commissures, a few fibers penetrating from the commissures into the deep pineal gland. To elucidate the origin of these fibers, the superior cervical ganglion was removed bilaterally in 10 animals, and the pineal complex was examined immunohistochemically. Two weeks after the ganglionectomy, the TH-IR and NPY-IR nerve fibers in the superficial pineal gland had almost completely disappeared. On the other hand, in the deep pineal and the pineal stalk, the TH-IR and NPY-IR fibers were still present after ganglionectomy. These data show that the deep pineal gland and the pineal stalk possess an extrasympathetic innervation by TH-IR and NPY-IR fibers. It is suggested that the extrasympathetic TH-IR and NPY-IR nerve fibers innervating the deep pineal and the pineal stalk originate from the brain.
在未经处理的大鼠以及双侧切除颈上神经节后的大鼠中，研究了酪氨酸羟化酶（TH）和神经肽Y（NPY）免疫反应性（IR）神经纤维在松果体复合体中的分布。在正常动物中，大量TH-IR和NPY-IR神经纤维存在于松果体被膜、血管周围间隙以及整个松果体浅层和深层松果体细胞之间的实质内。在后部和缰连合中发现少量TH-IR和NPY-IR神经纤维，有一些纤维从连合处穿入深层松果体。为阐明这些纤维的起源，对10只动物双侧切除颈上神经节，并对松果体复合体进行免疫组织化学检查。神经节切除术后两周，浅层松果体中的TH-IR和NPY-IR神经纤维几乎完全消失。另一方面，在深层松果体和松果体柄中，神经节切除术后TH-IR和NPY-IR纤维仍然存在。这些数据表明，深层松果体和松果体柄具有由TH-IR和NPY-IR纤维构成的交感神经外支配。提示支配深层松果体和松果体柄的交感神经外TH-IR和NPY-IR神经纤维起源于脑。
