Blue M L, Conrad P, Davis G, Kelley K A
Institute for Arthritis and Autoimmunity, Miles Research Center, West Haven, Connecticut 06516.
Cell Immunol. 1991 Nov;138(1):238-44. doi: 10.1016/0008-8749(91)90148-5.
Human fibroblasts were shown to enhance the proliferation of peripheral T cells in the presence of suboptimal concentrations of anti-CD2 antibodies (anti-T112 and anti-T113) and agonistic anti-VLA-4 antibody. Evidence is provided that the interaction of VLA-4 with immobilized fibronectin can enhance the proliferation of T cells subjected to suboptimal stimulation via CD2. Our results suggest that the fibroblast-stimulated T cell proliferative response to low doses of anti-T112 and T113 antibodies is due to the interaction of VLA-4 with fibroblast fibronectin. These findings also suggest a role for the fibronectin/VLA-4 interaction in the inflammatory process.
研究表明，在亚最佳浓度的抗CD2抗体（抗T112和抗T113）和激动性抗VLA-4抗体存在的情况下，人成纤维细胞可增强外周T细胞的增殖。有证据表明，VLA-4与固定化纤连蛋白的相互作用可增强经CD2亚最佳刺激的T细胞的增殖。我们的结果表明，成纤维细胞刺激的T细胞对低剂量抗T112和T113抗体的增殖反应是由于VLA-4与成纤维细胞纤连蛋白的相互作用。这些发现还表明纤连蛋白/VLA-4相互作用在炎症过程中起作用。
