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1
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.纤连蛋白和抗CD3抗体对CD4细胞的激活作用。由VLA-5纤连蛋白受体复合物介导的协同效应。
J Exp Med. 1989 Oct 1;170(4):1133-48. doi: 10.1084/jem.170.4.1133.
2
Activation of human CD4 T lymphocytes. Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.人CD4 T淋巴细胞的激活。纤连蛋白与CD4细胞上的VLA-5受体相互作用可诱导AP-1转录因子。
J Immunol. 1991 Jan 1;146(1):53-6.
3
Cross-linking of VLA/CD29 molecule has a co-mitogenic effect with anti-CD3 on CD4 cell activation in serum-free culture system.在无血清培养系统中，VLA/CD29分子的交联与抗CD3对CD4细胞活化具有协同促有丝分裂作用。
Eur J Immunol. 1991 Feb;21(2):319-25. doi: 10.1002/eji.1830210212.
4
Fibronectin promotes proliferation of naive and memory T cells by signaling through both the VLA-4 and VLA-5 integrin molecules.纤连蛋白通过VLA - 4和VLA - 5整合素分子发出信号来促进初始T细胞和记忆T细胞的增殖。
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5
VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.VLA-4通过纤连蛋白的CS1可变剪接结构域介导CD3依赖性CD4+ T细胞活化。
J Exp Med. 1990 Oct 1;172(4):1185-92. doi: 10.1084/jem.172.4.1185.
6
Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.通过VLA - 4和VLA - 5与纤连蛋白相互作用或VLA - 6与层粘连蛋白相互作用对静息CD4 + T细胞增殖反应的共刺激。
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7
Enhancement of CD2-mediated T cell activation by the interaction of VLA-4 with fibronectin.通过VLA-4与纤连蛋白的相互作用增强CD2介导的T细胞活化。
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8
CD4+CD45R+ cells are preferentially activated through the CD2 pathway.CD4+CD45R+细胞优先通过CD2途径被激活。
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Genipin crosslinking reduced the immunogenicity of xenogeneic decellularized porcine whole-liver matrices through regulation of immune cell proliferation and polarization.京尼平交联通过调节免疫细胞增殖和极化降低了异种脱细胞猪全肝基质的免疫原性。
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Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.Rv2468c，一种新型结核分枝杆菌蛋白，通过 VLA-5 共刺激人 CD4+T 细胞。
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Cytoprotective effects of a cyclic RGD peptide in steatotic liver cold ischemia and reperfusion injury.环RGD肽对脂肪变性肝脏冷缺血再灌注损伤的细胞保护作用
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Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease.在小鼠系统中，Toll样受体2直接介导的T细胞共刺激作为慢性炎性关节病的基础。
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本文引用的文献

1
Fibronectin is produced by human macrophages.纤连蛋白由人类巨噬细胞产生。
J Exp Med. 1980 Mar 1;151(3):602-13. doi: 10.1084/jem.151.3.602.
2
The differentiation and function of human T lymphocytes.人类T淋巴细胞的分化与功能。
Cell. 1980 Apr;19(4):821-7. doi: 10.1016/0092-8674(80)90072-0.
3
Antigens on human monocytes identified by monoclonal antibodies.通过单克隆抗体鉴定的人类单核细胞上的抗原。
J Immunol. 1981 Apr;126(4):1435-42.
4
Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes.血浆纤连蛋白可增强人外周血单核细胞对调理素化颗粒的吞噬作用。
J Exp Med. 1983 Jun 1;157(6):1844-54. doi: 10.1084/jem.157.6.1844.
5
Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.黏附蛋白功能的二元性：纤连蛋白及其生物活性肽片段可自动抑制纤连蛋白功能。
J Cell Biol. 1984 Jul;99(1 Pt 1):29-36. doi: 10.1083/jcb.99.1.29.
6
Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations.由一种单克隆抗体所界定的人类T4 +诱导性T细胞的异质性，该单克隆抗体划分出两个功能亚群。
J Immunol. 1982 Jan;128(1):463-8.
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Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis.青少年类风湿性关节炎患者体内针对免疫调节诱导细胞群体的自身抗体。
J Clin Invest. 1981 Mar;67(3):753-61. doi: 10.1172/JCI110092.
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Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man.人体辅助性和抑制性亚谱系中T淋巴细胞免疫调节亚群的剖析。
J Immunol. 1982 Nov;129(5):1997-2000.
9
Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex.从人血小板质膜中纯化糖蛋白IIb和III以及对钙依赖性糖蛋白IIb-III复合物的表征。
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
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纤连蛋白和抗CD3抗体对CD4细胞的激活作用。由VLA-5纤连蛋白受体复合物介导的协同效应。

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

作者信息

Matsuyama T, Yamada A, Kay J, Yamada K M, Akiyama S K, Schlossman S F, Morimoto C

机构信息

Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

出版信息

J Exp Med. 1989 Oct 1;170(4):1133-48. doi: 10.1084/jem.170.4.1133.

DOI:10.1084/jem.170.4.1133
PMID:2477485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189458/
Abstract

In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.

摘要

在本研究中，纤连蛋白与抗CD3抗体协同作用，在无血清培养系统中促进CD4细胞增殖。纤连蛋白分子的细胞黏附结构域及其他区域参与了这种协同作用。抗4B4(CDw29)抗体阻断了该系统中CD4细胞的活化。此外，抗4B4识别的分子组中的VLA-5蛋白作为CD4淋巴细胞上的纤连蛋白受体。VLA-5纤连蛋白受体主要表达于CD4+ CD45R-CDw29+细胞，可能部分促成了这些细胞的独特功能。