纤连蛋白和抗CD3抗体对CD4细胞的激活作用。由VLA-5纤连蛋白受体复合物介导的协同效应。
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.
作者信息
Matsuyama T, Yamada A, Kay J, Yamada K M, Akiyama S K, Schlossman S F, Morimoto C
机构信息
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
出版信息
J Exp Med. 1989 Oct 1;170(4):1133-48. doi: 10.1084/jem.170.4.1133.
Abstract
In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.
摘要
在本研究中，纤连蛋白与抗CD3抗体协同作用，在无血清培养系统中促进CD4细胞增殖。纤连蛋白分子的细胞黏附结构域及其他区域参与了这种协同作用。抗4B4(CDw29)抗体阻断了该系统中CD4细胞的活化。此外，抗4B4识别的分子组中的VLA-5蛋白作为CD4淋巴细胞上的纤连蛋白受体。VLA-5纤连蛋白受体主要表达于CD4+ CD45R-CDw29+细胞，可能部分促成了这些细胞的独特功能。
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Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.纤连蛋白和抗CD3抗体对CD4细胞的激活作用。由VLA-5纤连蛋白受体复合物介导的协同效应。
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