Christiansen Lene, Tan Qihua, Iachina Maria, Bathum Lise, Kruse Torben A, McGue Matthew, Christensen Kaare
Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Biol Psychiatry. 2007 Jan 15;61(2):223-30. doi: 10.1016/j.biopsych.2006.03.046. Epub 2006 Jun 27.
Depressed mood is a major concern in the elderly, with consequences for morbidity and mortality. Previous studies have demonstrated that genetic factors in depression and subsyndromal depressive symptoms are no less important in the elderly than during other life stages. Variations in genes included in the serotonin system have been suggested as risk factors for various psychiatric disorders but may also serve as candidates for normal variations in mood.
This study included 684 elderly Danish twins to investigate the influence of 11 polymorphisms in 7 serotonin system genes on the mean level of depression symptomatology assessed over several years, reflecting individuals' underlying mood level.
A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. We also found that a specific haplotype in VMAT2, the gene encoding the vesicular monoamine transporter, was significantly associated with depression symptoms in men (p= .007).
These results suggest that variations in genes encoding the components of serotonin metabolism may influence the basic mood level and that different genetic factors may apply in men and women.
情绪低落是老年人的一个主要问题，会对发病率和死亡率产生影响。先前的研究表明，抑郁症和亚综合征抑郁症状的遗传因素在老年人中与在其他生命阶段同样重要。血清素系统中包含的基因变异已被认为是各种精神疾病的风险因素，但也可能是情绪正常变异的候选因素。
本研究纳入了684对丹麦老年双胞胎，以调查7个血清素系统基因中的11个多态性对多年来评估的抑郁症状平均水平的影响，反映个体的潜在情绪水平。
发现负责血清素合成（TPH）、识别（5-HTR2A）和降解（MAOA）的基因序列变异与抑郁症状存在提示性关联，尽管这种影响通常仅限于男性。我们还发现，编码囊泡单胺转运体的基因VMAT2中的一种特定单倍型与男性的抑郁症状显著相关（p = 0.007）。
这些结果表明，血清素代谢成分编码基因的变异可能会影响基本情绪水平，而且不同的遗传因素可能适用于男性和女性。
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