老年人抑郁情绪与5-羟色胺2A受体基因变体之间的关联。
Association between depressed mood in the elderly and a 5-HTR2A gene variant.
作者信息
Jansson M, Gatz M, Berg S, Johansson B, Malmberg B, McClearn G E, Schalling M, Pedersen N L
机构信息
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):79-84. doi: 10.1002/ajmg.b.20016.
The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5-HTR2A gene promotor (-1438 G/A) and one in the 5-HT transporter gene (-925 C/A). DNA from a population-based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing trade mark. An association was found between the 5-HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, CI: 1.1-2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, CI: 1.4-4.4) was found for males and the A/A genotype, but not for females. The 5-HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly.
本研究旨在调查老年人抑郁情绪与血清素系统中两个候选单核苷酸多态性（SNP）之间的任何可能关联：一个位于5-羟色胺受体2A（5-HTR2A）基因启动子区（-1438 G/A），另一个位于5-羟色胺转运体基因（-925 C/A）。采用焦磷酸测序技术对瑞典一个基于人群的双胞胎样本（N = 1,592；平均年龄 = 73岁）的DNA进行基因分型。在总样本中，发现5-HTR2A基因启动子多态性与A/A基因型的抑郁情绪之间存在关联（比值比：1.5，置信区间：1.1 - 2.1）。当按性别分析样本时，发现男性中A/A基因型与抑郁情绪存在显著关联（比值比：2.4，置信区间：1.4 - 4.4），而女性中未发现此关联。在该老年人群中，5-羟色胺转运体基因与抑郁情绪无关联。这些结果表明，男性和女性在导致老年人抑郁情绪发生方面可能存在不同的遗传机制。
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