Kovács Z, Tallián F, Endröczi E
Endokrinologie. 1975 Jan;64(2):159-62.
Reserpine treatment produced a marked decrease of the in vitro binding of estradiol to the nuclear fraction of the uterus. A similar observation was made when reserpine was given into the incubation medium of uterine tissue. In contrast to these findings both in vitro and in vivo reserpine administration resulted in an increase of the estradiol binding to the nuclear fraction of the anterior pituitary in ovariectomized rats. The binding capacity of cytosol fraction after reserpine administration did not show significant alterations. In addition to these observations it is worth to mention that reserpine treatment resulted in a significant decrease of the estradiol-induced increase of uterus weight in ovariectomized rats.
利血平处理使雌二醇与子宫细胞核部分的体外结合显著减少。当将利血平加入子宫组织的孵育培养基中时，也观察到了类似的现象。与这些结果相反，无论是体外还是体内给予利血平，都导致去卵巢大鼠垂体前叶细胞核部分对雌二醇的结合增加。给予利血平后，胞质溶胶部分的结合能力没有明显变化。除了这些观察结果外，值得一提的是，利血平处理导致去卵巢大鼠中雌二醇诱导的子宫重量增加显著降低。
