Lee Byeong-Il, Lee Jae Sung, Lee Dong Soo, Nam Sang Hee, Choi Hyun Ju, Choi Heung Kook
Department of Nuclear Medicine and Institute of Radiation Medicine, Seoul National University Hospital, College of Medicine, Republic of Korea.
Comput Methods Programs Biomed. 2006 Jul;83(1):43-9. doi: 10.1016/j.cmpb.2006.03.008. Epub 2006 Jun 27.
Gated myocardial single photon emission computed tomography (SPECT) is being used for the diagnosis of coronary artery diseases. In this study, we developed new software for the quantification of volumes and ejection fraction (EF) on the gated myocardial SPECT data using a cylindrical model. Volumes and EF by developed software were validated by comparing with those quantified by quantitative gated SPECT (QGS) software. Cylinder model for left ventricular myocardium was used to eliminate background activity and count profiles across the myocardium were fitted to the Gaussian curve to determine the endocardial and epicardial boundary. End-diastolic volume (EDV), end-systolic volume (ESV) and EF were calculated using this boundary information. Gated myocardial SPECT was performed in 83 patients. EDV, ESV and EF values estimated using present method were compared to those obtained using the commercialized software QGS, and reproducibility in the parameter estimation was assessed. EF, EDV and ESV obtained using two methods were correlated well (correlation coefficients = 0.96, 0.96 and 0.98). The correlation between the parameters repetitively estimated from the same data set by an operator was very high (correlation coefficients = 0.96, 0.99 and 0.99 for EF, EDV and ESV). On the repeated acquisition, reproducibility was also high with correlation coefficients of 0.89, 0.97 and 0.98. The present software will be useful for the development of new parameters for describing the perfusion and function of the LV.
门控心肌单光子发射计算机断层扫描（SPECT）正用于冠状动脉疾病的诊断。在本研究中，我们开发了一种新软件，用于使用圆柱模型对门控心肌SPECT数据进行容积和射血分数（EF）的定量分析。通过与定量门控SPECT（QGS）软件定量分析的结果进行比较，对所开发软件得出的容积和EF进行了验证。使用左心室心肌的圆柱模型来消除背景活性，并将心肌的计数轮廓拟合为高斯曲线以确定心内膜和心外膜边界。利用该边界信息计算舒张末期容积（EDV）、收缩末期容积（ESV）和EF。对83例患者进行了门控心肌SPECT检查。将使用本方法估算的EDV、ESV和EF值与使用商业化软件QGS获得的值进行比较，并评估参数估计的重现性。两种方法获得的EF、EDV和ESV具有良好的相关性（相关系数分别为0.96、0.96和0.98）。由一名操作人员从同一数据集重复估算的参数之间的相关性非常高（EF、EDV和ESV的相关系数分别为0.96、0.99和0.99）。在重复采集时，重现性也很高，相关系数分别为0.89、0.97和0.98。本软件将有助于开发描述左心室灌注和功能的新参数。
