Castell-Conesa Joan, Aguadé-Bruix Santiago, García-Burillo Amparo, González José M, Canela Teresa, Oller Guillermo, Díez María J, Roca Isabel, Candell-Riera Jaume
Servicio de Medicina Nuclear, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Rev Esp Cardiol. 2004 Oct;57(10):931-8.
This study was designed to evaluate the reproducibility of ejection fraction (EF) and ventricular volume measurements obtained with single photon emission computed tomography (gated-SPECT), and to assess the correlation between EF values obtained with this method and blood pool planar radionuclide ventriculography.
A total of 55 patients were included (37 men, mean age 61.3 years) upon referral to two nuclear cardiology units for diagnosis (50%) or follow-up of known coronary artery disease. In a standard 2-day protocol, patients received a dose of [99mTc]tetrofosmin (800 MBq) at stress and at rest. Two resting gated-SPECT studies were performed. QGS software was used to obtain left ventricular EF, end-diastolic volume (EDV) and end-systolic volume (ESV). Forty-nine patients agreed to undergo blood pool ventriculography on the third day.
Interobserver variability was 0.5 (2.6)% (r=0.99) for EF, 1.9 (10.7) mL for EDV (r=0.98) and 0.5 (5.4) mL for ESV (r=0.99). Interassay variability was 2 (5.1)% (r=0.94) for EF, 4.5 (8.6) mL for EDV (r=0.99) and 3.4 (6.6) mL for ESV (r=0.99). The correlation between gated-SPECT EF and blood pool EF was suboptimal (r=0.75, 95%CI, 0.59-0.85).
There was excellent interobserver and interassay reproducibility for left ventricular functional parameters measured with gated-SPECT and QGS software, and this method can be used for serial evaluations of ventricular function. Although the correlation between values obtained with gated-SPECT and blood pool ventriculography was acceptable, the differences show that the two techniques cannot be considered equivalent.
本研究旨在评估单光子发射计算机断层扫描（门控SPECT）获得的射血分数（EF）和心室容积测量值的可重复性，并评估该方法获得的EF值与血池平面放射性核素心室造影之间的相关性。
共有55例患者（37例男性，平均年龄61.3岁）因诊断（50%）或已知冠状动脉疾病的随访转诊至两个核心脏病科。在标准的为期2天的方案中，患者在负荷和静息状态下接受一剂[99mTc]替曲膦（800MBq）。进行了两次静息门控SPECT研究。使用QGS软件获得左心室EF、舒张末期容积（EDV）和收缩末期容积（ESV）。49例患者同意在第三天进行血池心室造影。
EF的观察者间变异性为0.5（2.6）%（r=0.99），EDV为1.9（10.7）mL（r=0.98），ESV为0.5（5.4）mL（r=0.99）。测定间变异性为EF 2（5.1）%（r=0.94），EDV为4.5（8.6）mL（r=0.99），ESV为3.4（6.6）mL（r=0.99）。门控SPECT EF与血池EF之间的相关性欠佳（r=0.75，95%CI，0.59 - 0.85）。
使用门控SPECT和QGS软件测量左心室功能参数具有出色的观察者间和测定间可重复性，该方法可用于心室功能的系列评估。尽管门控SPECT与血池心室造影获得的值之间的相关性尚可，但差异表明这两种技术不能视为等效。
