Flügel Dominique, O'Toole Annette, Thompson Pamela J, Koepp Matthias J, Cercignani Mara, Symms Mark R, Foong Jacqueline
Department of Clinical and Experimental Epilepsy, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC 1N 3BG, UK.
Epilepsy Res. 2006 Oct;71(2-3):117-28. doi: 10.1016/j.eplepsyres.2006.05.018. Epub 2006 Jun 27.
To characterize the pattern of cognitive deficits in patients with temporal lobe epilepsy (TLE) and interictal (schizophrenia-like) psychosis and to examine the relationship between neuropsychological deficits and Magnetization transfer imaging.
Twenty patients with TLE and interictal psychosis were compared to 20 non-psychotic TLE patients. Patients were matched with respect to premorbid IQ, age and conventional MRI findings. A battery of neuropsychological tests was administered. The neuropsychological tests which showed significant group differences were used for correlational analysis with magnetization transfer ratio (MTR) which provides a quantitative measure of macromolecular structural integrity.
Patients with interictal psychosis were significantly more impaired on executive and semantic memory tasks than the non-psychotic TLE group. Vocabulary test scores correlated significantly with MTR reduction in the left fusiform gyrus in the psychotic but not the non-psychotic group.
In this study, patients with TLE and interictal psychosis were more cognitively impaired than non-psychotic TLE patients. Our findings suggest that the cognitive deterioration in these patients may occur as the illness progresses and the causes for this are probably multifactorial. Our study also provides further evidence that MTR may be useful in investigating structural correlates of cognitive impairment.
描述颞叶癫痫（TLE）合并发作间期（类精神分裂症样）精神病患者的认知缺陷模式，并研究神经心理学缺陷与磁化传递成像之间的关系。
将20例TLE合并发作间期精神病患者与20例非精神病性TLE患者进行比较。患者在病前智商、年龄和传统MRI检查结果方面进行匹配。进行了一系列神经心理学测试。对显示出显著组间差异的神经心理学测试与磁化传递率（MTR）进行相关分析，MTR可提供大分子结构完整性的定量测量。
发作间期精神病患者在执行和语义记忆任务上的受损程度明显高于非精神病性TLE组。在精神病组而非非精神病组中，词汇测试分数与左侧梭状回的MTR降低显著相关。
在本研究中，TLE合并发作间期精神病患者的认知障碍比非精神病性TLE患者更严重。我们的研究结果表明，这些患者的认知衰退可能随着疾病进展而发生，其原因可能是多因素的。我们的研究还提供了进一步的证据，表明MTR可能有助于研究认知障碍的结构相关性。
