Krappmann Sven
Institute of Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg-August University Göttingen, Grisebachstrasse 8, D-37077 Göttingen, Germany.
Trends Microbiol. 2006 Aug;14(8):356-64. doi: 10.1016/j.tim.2006.06.005. Epub 2006 Jun 27.
The unique nature of Aspergillus fungi represents a challenge for scrutinizing the attributes that render these saprophytic microorganisms pathogenic or allergenic under certain environmental circumstances. Recent publication of the genomic sequence from an isolate of the major pathogen Aspergillus fumigatus denotes enormous progress in aiming at cellular features and gene products that contribute to its pathogenicity. Latest developments to study virulence-related characteristics comprise profiling techniques, conditional gene inactivation and precise manipulation of the genome by means of gene targeting. Advances in assessing the virulence potential of particular mutant strains in alternative test systems complement these approaches.
曲霉属真菌的独特性质对于详细审查在特定环境条件下使这些腐生微生物具有致病性或变应原性的属性而言是一项挑战。近期主要病原菌烟曲霉分离株的基因组序列公布，标志着在针对有助于其致病性的细胞特征和基因产物方面取得了巨大进展。研究与毒力相关特征的最新进展包括分析技术、条件性基因失活以及通过基因靶向对基因组进行精确操作。在替代测试系统中评估特定突变菌株毒力潜力的进展补充了这些方法。
