Nafis Md M H, Quach Ziwei M, Al-Shaarani Amran A Q A, Muafa Mohammed H M, Pecoraro Lorenzo
School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
Pathogens. 2023 Sep 11;12(9):1154. doi: 10.3390/pathogens12091154.
Airborne fungi play an important role in air pollution and may have various negative effects on human health. In particular, fungi are pathogenic to humans and several domestic animals. In this work, strains isolated from airborne fungal communities sampled from different indoor and outdoor environments in Tianjin University were tested for pathogenicity on . Airborne fungi were sampled using an HAS-100B air sampler, over a one-year sampling period. Isolated fungal strains were identified based on morphological and molecular analysis. The -centered study was conducted as part of a larger work focusing on the total airborne fungal community in the analyzed environments, which yielded 173 fungal species. In this context, the genus showed the second-highest species richness, with 14 isolated species. Pathogenicity tests performed on male adults of through a bodily contact bioassay showed that all analyzed airborne species were pathogenic to fruit flies, with high insect mortality rates and shortened lifespan. All the studied fungi induced 100% mortality of fruit flies within 30 culture days, with one exception constituted by (39 days), while the shortest lifespan (17 days) was observed in fruit flies treated with . Our results allow us to hypothesize that the studied airborne fungal species may have a pathogenic effect on humans, given the affinity between fruit flies and the human immune system, and may help to explain the health risk linked with fungi exposure in densely populated environments.
空气传播的真菌在空气污染中起着重要作用，可能对人类健康产生各种负面影响。特别是，真菌对人类和几种家畜具有致病性。在这项工作中，对从天津大学不同室内和室外环境采集的空气传播真菌群落中分离出的菌株进行了致病性测试。在一年的采样期内，使用HAS - 100B空气采样器采集空气传播真菌。基于形态学和分子分析对分离出的真菌菌株进行鉴定。这项以……为中心的研究是一项更大规模工作的一部分，该工作聚焦于所分析环境中的空气传播真菌群落，共产生了173种真菌物种。在此背景下，……属显示出第二高的物种丰富度，有14个分离物种。通过身体接触生物测定法对……雄性成虫进行的致病性测试表明，所有分析的空气传播……物种对果蝇都具有致病性，果蝇死亡率高且寿命缩短。在30个培养日内，所有研究的真菌都导致果蝇100%死亡，只有……（39天）为例外，而在用……处理的果蝇中观察到最短寿命（17天）。鉴于果蝇与人类免疫系统之间的相似性，我们的结果使我们能够推测，所研究的空气传播真菌物种可能对人类有致病作用，并可能有助于解释在人口密集环境中接触……真菌所带来的健康风险。
