Galliot Brigitte, Miljkovic-Licina Marijana, de Rosa Renaud, Chera Simona
Department of Zoology and Animal Biology, University of Geneva, Sciences III, 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
Semin Cell Dev Biol. 2006 Aug;17(4):492-502. doi: 10.1016/j.semcdb.2006.05.005. Epub 2006 May 27.
The silencing of genes whose expression is restricted to specific cell types and/or specific regeneration stages opens avenues to decipher the molecular control of the cellular plasticity underlying head regeneration in hydra. In this review, we highlight recent studies that identified genes involved in the immediate cytoprotective function played by gland cells after amputation; the early dedifferentiation of digestive cells into blastema-like cells during head regeneration, and the early late proliferation of neuronal progenitors required for head patterning. Hence, developmental plasticity in hydra relies on spatially restricted and timely orchestrated cellular modifications, where the functions played by stem cells remain to be characterized.
那些表达仅限于特定细胞类型和/或特定再生阶段的基因的沉默，为破解九头蛇头部再生所依赖的细胞可塑性的分子控制开辟了道路。在这篇综述中，我们重点介绍了最近的研究，这些研究确定了与截肢后腺细胞发挥的即时细胞保护功能、头部再生过程中消化细胞向芽基样细胞的早期去分化以及头部模式形成所需的神经祖细胞的早期后期增殖有关的基因。因此，九头蛇的发育可塑性依赖于空间受限且适时协调的细胞修饰，而干细胞所发挥的功能仍有待确定。
