Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
J Cell Biol. 2012 Mar 5;196(5):553-62. doi: 10.1083/jcb.201105099.
Regeneration of complex structures after injury requires dramatic changes in cellular behavior. Regenerating tissues initiate a program that includes diverse processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell proliferation; furthermore, newly regenerated tissues must integrate polarity and positional identity cues with preexisting body structures. Gene knockdown approaches and transgenesis-based lineage and functional analyses have been instrumental in deciphering various aspects of regenerative processes in diverse animal models for studying regeneration.
复杂结构在受伤后需要通过细胞行为的剧烈变化来进行再生。再生组织启动了一个包含多种过程的程序，如伤口愈合、细胞死亡、去分化和干细胞（或祖细胞）增殖；此外，新再生的组织必须将极性和位置信息与预先存在的身体结构整合在一起。基因敲低方法和基于转基因的谱系和功能分析在破译不同动物模型中再生过程的各个方面方面发挥了重要作用，这些动物模型被用于研究再生。
