Giovannetti E, Danesi R, Mey V, Nannizzi S, Pasqualetti G, Del Tacca M
Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Italy.
Ann Oncol. 2006 May;17 Suppl 5:v17-19. doi: 10.1093/annonc/mdj943.
The use of gemcitabine in combination with chemotherapeutic agents, including cisplatin, pemetrexed and taxanes, is characterized by the enhancement of their anticancer activity. The analysis of the underlying pharmacodynamics has revealed that modulation of nucleotide pools, drug metabolism, and cellular DNA repair capability are the most common factors to explain the additive to synergistic interaction between gemcitabine and anticancer agents in several human cancers in vitro and in vivo.
吉西他滨与包括顺铂、培美曲塞和紫杉烷在内的化疗药物联合使用时，其特点是增强了它们的抗癌活性。对潜在药效学的分析表明，核苷酸池的调节、药物代谢和细胞DNA修复能力的调节是解释吉西他滨与抗癌药物在几种人类癌症的体外和体内实验中产生相加至协同相互作用的最常见因素。
