Trodella L, D'Angelillo R M, Ramella S, Cellini F, Ciresa M, Cesario A, Granone P
Radiotherapy Unit, University Campus Bio-Medico, Rome, Italy.
Ann Oncol. 2006 May;17 Suppl 5:v52-4. doi: 10.1093/annonc/mdj950.
Gemcitabine (2'-2'-difluorodeoxycytidine) is a well-known cytotoxic drug and a potent radio-enhancer. We herein report the in vitro evidence of its activity, and the clinical experiences when this drug is administered concurrently with radiation. The phase I-II trials are analyzed, focusing on the recent ability to deliver irradiation with low incidence of side effects.
吉西他滨（2'-2'-二氟脱氧胞苷）是一种知名的细胞毒性药物和强效放射增敏剂。我们在此报告其体外活性证据，以及该药物与放疗同时使用时的临床经验。对I-II期试验进行了分析，重点关注近期低副作用发生率的放疗能力。
