Bob Petr, Glaslova Katerina, Susta Marek, Jasova Denisa, Raboch Jiri
Centre for Neuropsychiatric Research of Traumatic Stress, and Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Neuro Endocrinol Lett. 2006 Jun;27(3):321-6.
According to recent evidence, trauma and stress are important etiological factors in pathogenesis of schizophrenia. However, the hypothetical influence of traumatic stress on epileptic-like (or kindling) phenomena in schizophrenia is at this time unclear.
In order to discover the influence of trauma, 82 patients with a diagnosis of paranoid schizophrenia and 50 healthy controls were assessed for symptoms of dissociation, traumatic stress and psycho-sensory symptoms of epileptic origin.
We have found significant traumatization and dissociation in patients who met the cut-off score for psychosensory epileptic-like symptoms and also significant correlations among these measures have been found.
These data suggest a certain role of epileptic-like phenomena in dissociative states in schizophrenia and are in accordance with rare intracranial EEG findings which suggest a certain role of epileptiform events in schizophrenia.
根据最近的证据，创伤和应激是精神分裂症发病机制中的重要病因。然而，创伤性应激对精神分裂症中癫痫样（或点燃）现象的假设性影响目前尚不清楚。
为了探究创伤的影响，对82例诊断为偏执型精神分裂症的患者和50名健康对照者进行了分离症状、创伤性应激和癫痫源性心理感觉症状的评估。
我们发现，在符合心理感觉性癫痫样症状临界值的患者中存在显著的创伤和分离现象，并且这些指标之间也存在显著相关性。
这些数据表明癫痫样现象在精神分裂症的分离状态中具有一定作用，并且与罕见的颅内脑电图结果一致，后者表明癫痫样事件在精神分裂症中具有一定作用。
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