Bob Petr, Susta Marek, Glaslova Katerina, Fedor-Freybergh Peter G, Pavlat Josef, Miklosko Jozef, Raboch Jiri
Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Neuro Endocrinol Lett. 2007 Dec;28(6):868-74.
Recent evidence indicates frequent EEG abnormalities in dissociated patients. This evidence is in agreement with findings that in certain psychiatric patients, psychosensory symptoms of epileptogenic nature, the so-called complex partial seizure-like symptoms occur. With respect to these findings, a hypothesis examined in this study states that increased level of experienced traumatic stress and dissociation in pathological conditions such as schizophrenia or depression relates to increased score of complex partial seizure-like symptoms. Also is suggested that the complex partial seizure-like symptoms might be related to unilateral hemispheric electrophysiological dysfunction, stress and dissociation.
Psychometric assessment of dissociation, stress and measurement of right-left asymmetry of bilateral EDA in patients with schizophrenia (N=34) and depression (N=41) in comparison to healthy controls (N=36).
Results indicate that increased traumatic stress and dissociation in both groups of patients significantly relate to increased level of complex partial seizure-like symptoms, and may cause the right-left EDA asymmetry.
The data suggest relationship between left-hemispheric asymmetry and sympathetic over-activation in schizophrenia, and between right-hemispheric asymmetry with sympathetic under-activation in depression.
近期证据表明分离性障碍患者脑电图异常频繁。这一证据与某些精神科患者出现具有致痫性质的心理感觉症状（即所谓的复杂部分性发作样症状）的研究结果一致。基于这些发现，本研究检验的一个假设指出，在精神分裂症或抑郁症等病理状态下，经历的创伤性应激水平和分离增加与复杂部分性发作样症状得分增加有关。还表明复杂部分性发作样症状可能与单侧半球电生理功能障碍、应激和分离有关。
对精神分裂症患者（N = 34）和抑郁症患者（N = 41）进行分离、应激的心理测量评估以及双侧皮肤电活动（EDA）左右不对称性测量，并与健康对照组（N = 36）进行比较。
结果表明，两组患者创伤性应激和分离增加均与复杂部分性发作样症状水平升高显著相关，并可能导致皮肤电活动左右不对称。
数据表明精神分裂症患者左半球不对称与交感神经激活过度之间存在关联，而抑郁症患者右半球不对称与交感神经激活不足之间存在关联。
