Geier David A, Geier Mark R
The Institute for Chronic Illnesses, Inc., Silver Spring, MD 20905, USA.
Neuro Endocrinol Lett. 2006 Aug;27(4):401-13.
Thimerosal is an ethylmercury-containing compound (49.6% mercury by weight) used as at the preservative level in vaccines (0.005% to 0.01%).
Statistical modeling in a meta-analysis epidemiological assessment of the Vaccine Adverse Event Reporting System (VAERS) for neurodevelopment disorders (NDs) reported following Diphtheria-Tetanus-whole-cell-Pertussis (DTP) vaccines in comparison to Diphtheria-Tetanus-whole-cell-Pertussis-Haemophilus Influenzae Type b (DTPH) vaccines (administered: 1994-1997) and following Thimerosal-containing Diphtheria-Tetanus-acellular-Pertussis (DTaP), vaccines in comparison to Thimerosal-free DTaP vaccines (administered: 1997-2000), was undertaken.
Significantly increased adjusted (sex, age, vaccine type, vaccine manufacturer) risks of autism, speech disorders, mental retardation, personality disorders, thinking abnormalities, ataxia, and NDs in general, with minimal systematic error or confounding, were associated with TCV exposure.
It is clear from the results of the present epidemiological study and other recently published data associating mercury exposure with childhood NDs, additional ND research should be undertaken in the context of evaluating mercury-associated exposures, especially from Thimerosal-containing vaccines.
硫柳汞是一种含乙基汞的化合物（按重量计汞含量为49.6%），在疫苗中用作防腐剂（含量为0.005%至0.01%）。
对疫苗不良事件报告系统（VAERS）进行荟萃分析流行病学评估，采用统计建模，比较白喉-破伤风-全细胞百日咳（DTP）疫苗与白喉-破伤风-全细胞百日咳-乙型流感嗜血杆菌（DTPH）疫苗（接种时间：1994 - 1997年）接种后报告的神经发育障碍（NDs）情况，以及含硫柳汞的白喉-破伤风-无细胞百日咳（DTaP）疫苗与不含硫柳汞的DTaP疫苗（接种时间：1997 - 2000年）接种后报告的神经发育障碍情况。
与接种含硫柳汞疫苗（TCV）相关的是，在调整了性别、年龄、疫苗类型、疫苗生产商等因素后，自闭症、言语障碍、智力迟钝、人格障碍、思维异常、共济失调以及总体神经发育障碍的风险显著增加，且系统误差或混杂因素极小。
从本流行病学研究结果以及其他最近发表的将汞暴露与儿童神经发育障碍相关联的数据可以清楚地看出，应在评估与汞相关的暴露，尤其是含硫柳汞疫苗暴露的背景下，开展更多关于神经发育障碍的研究。
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