一项对1994年至2000年在美国接种疫苗后神经发育障碍的荟萃分析流行病学评估。

A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States.

作者信息

Geier David A, Geier Mark R

机构信息

The Institute for Chronic Illnesses, Inc., Silver Spring, MD 20905, USA.

出版信息

Neuro Endocrinol Lett. 2006 Aug;27(4):401-13.

PMID:16807526

Abstract

BACKGROUND

Thimerosal is an ethylmercury-containing compound (49.6% mercury by weight) used as at the preservative level in vaccines (0.005% to 0.01%).

METHODS

Statistical modeling in a meta-analysis epidemiological assessment of the Vaccine Adverse Event Reporting System (VAERS) for neurodevelopment disorders (NDs) reported following Diphtheria-Tetanus-whole-cell-Pertussis (DTP) vaccines in comparison to Diphtheria-Tetanus-whole-cell-Pertussis-Haemophilus Influenzae Type b (DTPH) vaccines (administered: 1994-1997) and following Thimerosal-containing Diphtheria-Tetanus-acellular-Pertussis (DTaP), vaccines in comparison to Thimerosal-free DTaP vaccines (administered: 1997-2000), was undertaken.

RESULTS

Significantly increased adjusted (sex, age, vaccine type, vaccine manufacturer) risks of autism, speech disorders, mental retardation, personality disorders, thinking abnormalities, ataxia, and NDs in general, with minimal systematic error or confounding, were associated with TCV exposure.

CONCLUSION

It is clear from the results of the present epidemiological study and other recently published data associating mercury exposure with childhood NDs, additional ND research should be undertaken in the context of evaluating mercury-associated exposures, especially from Thimerosal-containing vaccines.

摘要

背景

硫柳汞是一种含乙基汞的化合物（按重量计汞含量为49.6%），在疫苗中用作防腐剂（含量为0.005%至0.01%）。

方法

对疫苗不良事件报告系统（VAERS）进行荟萃分析流行病学评估，采用统计建模，比较白喉-破伤风-全细胞百日咳（DTP）疫苗与白喉-破伤风-全细胞百日咳-乙型流感嗜血杆菌（DTPH）疫苗（接种时间：1994 - 1997年）接种后报告的神经发育障碍（NDs）情况，以及含硫柳汞的白喉-破伤风-无细胞百日咳（DTaP）疫苗与不含硫柳汞的DTaP疫苗（接种时间：1997 - 2000年）接种后报告的神经发育障碍情况。