Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia (UBC), 828 W. 10th Ave., Vancouver, BC, V5Z 1L8, Canada.
Immunol Res. 2013 Jul;56(2-3):304-16. doi: 10.1007/s12026-013-8403-1.
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.
我们研究了在不同条件下，通过不同途径给予铝后对人类和动物的神经毒性，并对各种相关疾病状态进行了综述。文献清楚地表明，铝对神经系统的影响在整个年龄段都是负面的。在成年人中，铝暴露可导致明显与年龄相关的神经功能缺损，类似于阿尔茨海默病，并与该病以及关岛变异型、ALS-PDC 相关。在动物模型中也发现了类似的结果。此外，为了模拟海湾战争综合征和相关神经功能缺损而注射铝佐剂，会导致年轻雄性小鼠出现 ALS 表型。在幼儿中，接受的含铝佐剂的儿科疫苗数量与自闭症谱系障碍的发生率之间存在高度显著的相关性。铝诱导的神经毒性的许多特征可能部分源于自身免疫反应，是 ASIA 综合征的一部分。
