Geier David A, Kern Janet K, Hooker Brian S, King Paul G, Sykes Lisa K, Geier Mark R
Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA.
Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA ; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
N Am J Med Sci. 2014 Oct;6(10):519-31. doi: 10.4103/1947-2714.143284.
Within the first 3 years of life, the brain develops rapidly. Its development is characterized by critical developmental periods for speech, vision, hearing, language, balance, etc.; and alteration in any of the processes occurring in those critical periods can lead to specific delays in development.
The present study evaluated the potential toxic effects of organic-mercury exposure from Thimerosal (49.55% mercury by weight) in childhood vaccines and its hypothesized possible relationship with specific delays in development.
A hypothesis testing case-control study was undertaken to evaluate the relationship between exposure to Thimerosal-containing hepatitis B vaccines administered at specific intervals in the first 6 months among cases diagnosed with specific delays in development and controls born between 1991-2000, utilizing data in the Vaccine Safety Datalink database.
Cases were significantly more likely than controls to have received increased organic-mercury from Thimerosal-containing hepatitis B vaccine administered in the first, second, and sixth month of life.
Though routine childhood vaccination may be an important public health tool to reduce the morbidity and mortality associated with infectious diseases, the present study supports an association between increasing organic-mercury exposure from Thimerosal-containing childhood vaccines and the subsequent risk of specific delays in development among males and females.
在生命的头3年里，大脑发育迅速。其发育的特点是存在言语、视觉、听觉、语言、平衡等关键发育时期；这些关键时期内发生的任何过程的改变都可能导致特定的发育迟缓。
本研究评估了儿童疫苗中硫柳汞（按重量计含汞49.55%）的有机汞暴露的潜在毒性作用及其与特定发育迟缓的假设可能关系。
利用疫苗安全数据链数据库中的数据，进行了一项假设检验病例对照研究，以评估在1991 - 2000年出生的、被诊断为有特定发育迟缓的病例和对照中，在出生后头6个月以特定间隔接种含硫柳汞乙肝疫苗的暴露情况之间的关系。
与对照组相比，病例组在出生后的第一、第二和第六个月接种含硫柳汞乙肝疫苗后，更有可能接触到更多的有机汞。
尽管常规儿童疫苗接种可能是降低与传染病相关的发病率和死亡率的重要公共卫生工具，但本研究支持含硫柳汞儿童疫苗中有机汞暴露增加与随后男性和女性特定发育迟缓风险之间存在关联。
