Perret F, Mooser V, Hayoz D, Tardy Y, Meister J J, Etienne J D, Farine P A, Marazzi A, Burnier M, Nussberger J
Division of Hypertension, University Hospital, Lausanne, Switzerland.
Hypertension. 1991 Oct;18(4 Suppl):II77-83. doi: 10.1161/01.hyp.18.4_suppl.ii77.
A new high-precision ultrasonic device was developed to determine noninvasively arterial compliance as a function of blood pressure. Because of the nonlinear elastic properties of arterial walls, measurements of compliance can be appropriately compared only if obtained over a range of pressures. This apparatus was used to evaluate in a double-blind, parallel fashion the effect of three different antihypertensive drugs and of a placebo on radial artery compliance. Thirty-two normotensive volunteers were randomly allocated to an 8-day, once-a-day oral treatment with either a placebo, 100 mg atenolol, 20 mg nitrendipine, or 20 mg lisinopril. Blood pressure, heart rate, radial artery diameter, and arterial compliance were measured immediately before as well as 6 hours after dosing on the first and last days of the study. On the eighth day of administration, within 6 hours after dosing, lisinopril induced an acute increase in radial artery diameter, from 2.99 +/- 0.06 to 3.28 +/- 0.09 mm (mean +/- SEM, p less than 0.01). The compliance-pressure curve was shifted upward on day 1 (p less than 0.01) as well as on day 8 (p less than 0.05). None of the other drugs induced any significant modification of these parameters. Arterial compliance has a strong nonlinear dependency on intra-arterial pressure and therefore has to be defined as a function of pressure. Antihypertensive drugs acting by different mechanisms may have different effects on the mechanical properties of large arteries.
开发了一种新型高精度超声设备，用于无创测定动脉顺应性与血压的关系。由于动脉壁的非线性弹性特性，只有在一定压力范围内获得的顺应性测量值才能进行适当比较。该仪器用于以双盲、平行方式评估三种不同抗高血压药物和一种安慰剂对桡动脉顺应性的影响。32名血压正常的志愿者被随机分配接受为期8天、每天一次的口服治疗，治疗药物分别为安慰剂、100毫克阿替洛尔、20毫克尼群地平或20毫克赖诺普利。在研究的第一天和最后一天给药前以及给药后6小时，测量血压、心率、桡动脉直径和动脉顺应性。在给药后的第8天，给药后6小时内，赖诺普利使桡动脉直径急性增加，从2.99±0.06毫米增加到3.28±0.09毫米（平均值±标准误，p<0.01）。第1天（p<0.01）和第8天（p<0.05）顺应性-压力曲线均向上移动。其他药物均未引起这些参数的任何显著变化。动脉顺应性对动脉内压力有很强的非线性依赖性，因此必须定义为压力的函数。通过不同机制起作用的抗高血压药物可能对大动脉的力学性能有不同影响。
