Meguro Shinichi, Osaki Noriko, Matsuo Noboru, Tokimitsu Ichiro
Biological Science Laboratories, Kao Corporation, Tochigi, Japan.
Lipids. 2006 Apr;41(4):347-55. doi: 10.1007/s11745-006-5105-7.
The effects of DAG oil and TAG oil on impaired glucose tolerance in rats that were fed a diet containing high levels of sucrose were compared. Male Wistar rats (8 wk old and 32 wk old) were fed either high-sucrose (57.5% sucrose w/w) or control diets containing either 10% (w/w) DAG or TAG oil with a similar FA composition for 48 wk in 8-wk-old rats and for 24 wk in 32-wk-old rats. Plasma lipids, the size of the islets of Langerhans, and insulin, glucose, and adipocytokine levels were measured. An oral glucose tolerance test (OGTT) was carried out during the study period. For rats in both age groups that were fed a high-sucrose diet, the DAG oil group had lower plasma glucose and insulin response in an OGTT, and lower homeostasis model assessment-R levels, than the TAG oil group. Furthermore, in 8-wk-old rats that were fed a high-sucrose diet, the DAG oil group accumulated less visceral fat and showed suppressed decreases [corrected] of plasma adiponectin and [corrected] increases of plasma insulin, leptin, and the size of islet of Langerhans compared with the TAG oil group. No difference in the OGTT was found between the DAG and TAG oil groups in either age group of rats fed a control diet. In conclusion, these results suggest that DAG oil ingestion prevents the high-sucrose-diet-induced development of impaired glucose tolerance compared with TAG oil ingestion.
比较了二酰甘油（DAG）油和三酰甘油（TAG）油对喂食高蔗糖饮食大鼠糖耐量受损的影响。雄性Wistar大鼠（8周龄和32周龄）分别喂食高蔗糖（57.5%蔗糖，w/w）或对照饮食，对照饮食含有10%（w/w）的DAG或TAG油，其脂肪酸组成相似，8周龄大鼠喂食48周，32周龄大鼠喂食24周。测量血浆脂质、胰岛大小以及胰岛素、葡萄糖和脂肪细胞因子水平。在研究期间进行口服葡萄糖耐量试验（OGTT）。对于两个年龄组中喂食高蔗糖饮食的大鼠，DAG油组在OGTT中的血浆葡萄糖和胰岛素反应较低，且稳态模型评估-R水平低于TAG油组。此外，在喂食高蔗糖饮食的8周龄大鼠中，与TAG油组相比，DAG油组的内脏脂肪积累较少，血浆脂联素的降低[校正后]以及血浆胰岛素、瘦素和胰岛大小的增加[校正后]受到抑制。在喂食对照饮食的两个年龄组大鼠中，DAG油组和TAG油组的OGTT没有差异。总之，这些结果表明，与摄入TAG油相比，摄入DAG油可预防高蔗糖饮食诱导的糖耐量受损的发展。
