Niizeki H, Inoko H, Narimatsu H, Takata H, Sonoda A, Tadakuma T, Ando A, Tsuji K, Hashimoto T, Nishikawa T
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Hum Immunol. 1991 Aug;31(4):246-50. doi: 10.1016/0198-8859(91)90095-q.
We investigated the HLA class II antigens in 30 Japanese cases of pemphigus, 17 cases of pemphigus vulgaris (PV) and 13 cases of pemphigus foliaceus (PF), by both serologic and restriction fragment length polymorphism (RFLP) analyses. We detected two major haplotypes susceptible to PV, i.e., DRw12-DQw7 and DRw6-DQw5. In contrast, DR2 was absent in PV. RFLP analyses showed that DRw6 PV patients had a disease-associated restriction fragment representing DQw5, the same association as that found in DRw6 Jewish PV patients. However, DRw12 Japanese PV patients had DQw7, whereas DR4 Jewish PV patients had DQw8. On the other hand, all 13 PF patients were serologically typed for DQw1, which could not be further subdivided into DQw5 by RFLP analyses. These results suggest that Japanese and Jewish PV patients may be immunogenetically closely related to each other, but Japanese PV patients appear to be immunogenetically different from Japanese PF patients.
我们通过血清学分析和限制性片段长度多态性（RFLP）分析，对30例日本天疱疮患者（其中17例寻常型天疱疮（PV）和13例落叶型天疱疮（PF））的HLA II类抗原进行了研究。我们检测到两种易患PV的主要单倍型，即DRw12 - DQw7和DRw6 - DQw5。相比之下，PV患者中不存在DR2。RFLP分析显示，DRw6 PV患者有一个代表DQw5的疾病相关限制性片段，这与在DRw6犹太PV患者中发现的关联相同。然而，DRw12日本PV患者有DQw7，而DR4犹太PV患者有DQw8。另一方面，所有13例PF患者血清学分型均为DQw1，通过RFLP分析无法进一步细分为DQw5。这些结果表明，日本和犹太PV患者在免疫遗传学上可能彼此密切相关，但日本PV患者在免疫遗传学上似乎与日本PF患者不同。
