通过基质辅助激光解吸电离飞行时间质谱法筛查神经毒剂降解产物
Screening of nerve agent degradation products by MALDI-TOFMS.
作者信息
Shu You-Ren, Su An-Kai, Liu Ju-Tsung, Lin Cheng-Huang
机构信息
Department of Chemistry, National Taiwan Normal University, 88 Section 4, Tingchow Road, Taipei, Taiwan.
出版信息
Anal Chem. 2006 Jul 1;78(13):4697-701. doi: 10.1021/ac060007k.
A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin (GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. For comparison, CHCA (alpha-cyano-4-hydroxycinnamic acid) and DCCA (7-(diethylamino)coumarin-3-carboxylic acid) were used as the MALDI-matrix when the third harmonic generation (355 nm) of a Nd:YAG laser and a hydrogen Raman laser (multifrequency laser) were used, respectively. The method permitted the five nerve agent degradation products to be screened rapidly and successfully, suggesting that it has the potential for use as a routine monitoring tool.
描述了一种通过基质辅助激光解吸电离飞行时间质谱快速筛选神经毒剂降解产物的新方法。选择了五种标准产物作为模型化合物，包括异丙基甲基膦酸（IMPA）、频哪基甲基膦酸（PMPA）、乙基甲基膦酸（EMPA）、异丁基甲基膦酸（i-BuMPA）和环己基甲基膦酸（CHMPA），它们分别是沙林（GB）、梭曼（GD）、VX、俄罗斯VX（RVX）和GF的降解产物。为作比较，当分别使用Nd:YAG激光的三倍频（355 nm）和氢拉曼激光（多频激光）时，使用α-氰基-4-羟基肉桂酸（CHCA）和7-（二乙氨基）香豆素-3-羧酸（DCCA）作为基质辅助激光解吸电离（MALDI）基质。该方法能够快速且成功地筛选出这五种神经毒剂降解产物，表明其有作为常规监测工具的潜力。
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