Humphreys H, Johnson E M, Warnock D W, Willatts S M, Winter R J, Speller D C
Department of Microbiology, Bristol Royal Infirmary.
J Hosp Infect. 1991 Jul;18(3):167-77. doi: 10.1016/0195-6701(91)90141-t.
Over a 5-month period, six patients in a general intensive therapy unit became colonized by Aspergillus species including Aspergillus fumigatus, and invasive infection occurred in at least two of them. Broncho-alveolar lavage was unhelpful in discriminating between infection and colonization. The source of infection was presumed to be disturbance of an accumulation of spores in fibrous insulation material above the perforated metal ceiling. Patients in such units without clearly identifiable defects of defence against infection may be at risk from aspergillosis. The risk can be reduced by improved hospital design, satisfactory ventilation and thorough regular cleaning of environmental surfaces.
在5个月的时间里，一家综合重症监护病房的6名患者被包括烟曲霉在内的曲霉菌种定植，其中至少2人发生了侵袭性感染。支气管肺泡灌洗在区分感染和定植方面并无帮助。感染源被推测为穿孔金属天花板上方纤维绝缘材料中孢子堆积物受到扰动。在没有明确可识别的抗感染防御缺陷的此类病房中的患者可能有患曲霉病的风险。通过改进医院设计、保证通风良好以及定期彻底清洁环境表面，可降低这种风险。
