Giménez Mónica, Junqué Carme, Narberhaus Ana, Bargalló Núria, Botet Francesc, Mercader Josep Maria
Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, and Department of Obstetrics and Gynecology, Pediatrics, Radiology and Physics Medicine, Hospital Clinic, Spain.
Neuroimage. 2006 Oct 1;32(4):1485-98. doi: 10.1016/j.neuroimage.2006.05.013. Epub 2006 Jun 30.
Very preterm birth (VPTB) is an important risk factor for white matter (WM) damage. We used voxel-based morphometry (VBM) to examine regional WM brain abnormalities in 50 adolescents with antecedents of very preterm birth (VPTB) without evidence of WM damage on T2-weighted MRI. This group was compared with a group of 50 subjects born at term and matched for age, handedness and socio-cultural status. We also examined the relationship between WM changes and gestational age (GA) and weight (GW) at birth in VPTB subjects. Both modulated and unmodulated VBM analyses showed significant abnormalities in several WM brain regions in the VPTB group, involving all the cerebral lobes. However, density analyses (unmodulated data) mainly identified periventricular damage and the involvement of the longitudinal fascicles while volume analyses (modulated data) detected WM decreases in regions distant from the ventricular system, located at the origin and end of the long fascicles. A significant correlation was found between WM decreases and both GA and GW in various brain regions: the lower the GA and GW, the lower the WM integrity. This study supports the current view that widespread white matter impairment is associated with immature birth.
极早产（VPTB）是白质（WM）损伤的一个重要危险因素。我们使用基于体素的形态学测量（VBM）方法，对50名有极早产病史且在T2加权磁共振成像（MRI）上无WM损伤证据的青少年的脑区WM异常进行了检查。将该组与50名足月出生、年龄、利手和社会文化地位相匹配的受试者组成的对照组进行比较。我们还研究了VPTB受试者的WM变化与出生时胎龄（GA）和体重（GW）之间的关系。调制和未调制的VBM分析均显示，VPTB组的几个脑区WM存在显著异常，累及所有脑叶。然而，密度分析（未调制数据）主要发现脑室周围损伤和纵向束的受累情况，而体积分析（调制数据）则检测到远离脑室系统的区域WM减少，这些区域位于长束的起始和末端。在不同脑区，WM减少与GA和GW均存在显著相关性：GA和GW越低，WM完整性越低。本研究支持目前的观点，即广泛的白质损伤与早产有关。
