Jani Ashesh B
The Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA.
Cancer Invest. 2006 Apr-May;24(3):318-27. doi: 10.1080/07357900600633775.
The goals of this article are to review the application of the number needed to treat (NNT) concept to selected clinical problems in prostate cancer radiotherapy. Particular emphasis will be placed on (1) comparison of radiotherapy with other treatment options for early-stage disease, (2) the role of hormone therapy in addition to radiotherapy over a spectrum of disease presentation, and (3) systematic comparison of adjuvant versus salvage radiotherapy in the post-prostatectomy setting. Limitations of NNT calculations based on non-randomized comparisons also are discussed.
本文的目的是回顾治疗所需人数(NNT)概念在前列腺癌放疗中选定临床问题的应用。将特别强调:(1)早期疾病放疗与其他治疗选择的比较;(2)在一系列疾病表现中,除放疗外激素治疗的作用;(3)前列腺切除术后辅助放疗与挽救性放疗的系统比较。还将讨论基于非随机比较的NNT计算的局限性。