Convento E, Midena E, Dorigo M T, Maritan V, Cavarzeran F, Fregona I A
Department of Ophthalmology, University of Padova, Via Giustiniani, 2, Padova 35128, Italy.
Br J Ophthalmol. 2006 Nov;90(11):1398-403. doi: 10.1136/bjo.2006.092973. Epub 2006 Jun 29.
To evaluate, with fundus perimetry, the peripapillary differential light threshold (DLT) in eyes with glaucoma and ocular hypertension (OHT), and compare it with peripapillary retinal nerve fibre layer (RNFL) thickness.
35 glaucomatous, 29 OHT and 24 control eyes were included. Peripapillary DLT at 1 degrees from the optic nerve head was quantified with fundus perimetry; peripapillary RNFL thickness was measured over the same area by optical coherence tomography.
Mean (SD) peripapillary DLT was 19.2 (1.7), 17.6 (4.2) and 10.1 (6.9) dB in control, OHT and glaucomatous eyes, respectively (p<0.001). Mean (SD) RNFL thickness was 98.4 (35.3), 83.9 (35.1) and 55.8 (28.2) microm, respectively (p<0.001). Mean peripapillary DLT showed higher sensitivity and specificity in differentiating the three groups compared with RNFL thickness.
Progressive, significant reduction of peripapillary DLT was documented in OHT and glaucomatous eyes compared with controls (p<0.001). DLT reduction parallels RNFL reduction.
通过眼底视野检查评估青光眼和高眼压症（OHT）患者的视乳头周围微分光阈值（DLT），并将其与视乳头周围视网膜神经纤维层（RNFL）厚度进行比较。
纳入35只青光眼患眼、29只高眼压症患眼和24只对照眼。使用眼底视野检查定量测量距视神经乳头1度处的视乳头周围DLT；通过光学相干断层扫描测量同一区域的视乳头周围RNFL厚度。
对照组、高眼压症组和青光眼组患眼的平均（标准差）视乳头周围DLT分别为19.2（1.7）dB、17.6（4.2）dB和10.1（6.9）dB（p<0.001）。平均（标准差）RNFL厚度分别为98.4（35.3）μm、83.9（35.1）μm和55.8（28.2）μm（p<0.001）。与RNFL厚度相比，平均视乳头周围DLT在区分这三组时显示出更高的敏感性和特异性。
与对照组相比，高眼压症和青光眼患眼中视乳头周围DLT出现了进行性、显著降低（p<0.001）。DLT降低与RNFL降低平行。
