Nikjoo H, Goodhead D T, Charlton D E, Paretzke H G
Medical Research Council Radiobiology Unit, Didcot, Oxon, UK.
Int J Radiat Biol. 1991 Nov;60(5):739-56. doi: 10.1080/09553009114552561.
Calculations of energy deposition in cylindrical target volumes of diameter and height 1-100 nm, including those similar to the dimensions of biological molecules and structures such as DNA, nucleosomes and chromatin fibre, have been made. The calculations used the Monte Carlo track structure program MOCA8B for electrons of initial energy 0.1-100 keV. Details of the calculation are presented, as well as a selection of results. The frequency distributions of energy deposition events per gray per target, placed at random in a homogeneous aqueous medium, are given for uniform irradiation with monoenergetic electrons of various energies. The frequency distributions have been used to predict the initial biophysical parameters such as relative effectiveness for initial damage. These suggest that the final biological effects which depend on complex local damage may show substantial variations in biological effectiveness for different low linear energy transfer radiations, whereas those that depend on simple local damage may not.
已对直径和高度为1 - 100纳米的圆柱形目标体积内的能量沉积进行了计算，其中包括与生物分子和结构（如DNA、核小体和染色质纤维）尺寸相似的目标体积。计算使用了蒙特卡罗径迹结构程序MOCA8B，用于初始能量为0.1 - 100 keV的电子。文中给出了计算细节以及部分结果。对于在均匀水介质中随机放置的目标，给出了用各种能量的单能电子进行均匀辐照时，每个目标每格雷能量沉积事件的频率分布。这些频率分布已被用于预测初始生物物理参数，如初始损伤的相对有效性。这表明，依赖于复杂局部损伤的最终生物学效应，对于不同的低线性能量转移辐射，其生物学有效性可能会有显著变化，而依赖于简单局部损伤的效应可能不会。
