Chappel M C, Ferrario C M
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1095, USA.
Kidney Int. 2006 Jul;70(1):8-10. doi: 10.1038/sj.ki.5000321.
The discovery of angiotensin-converting enzyme 2 (ACE-2) has revealed a far more complex enzymatic cascade that may influence the renin-angiotensin system within the kidney, specifically the expression of the functional products angiotensin II (Ang II) and Ang-(1-7). The regulation of this critical system involved in blood pressure control must now encompass the integral relationship of ACE and ACE-2 activities.
血管紧张素转换酶2（ACE-2）的发现揭示了一个更为复杂的酶促级联反应，该反应可能影响肾脏内的肾素-血管紧张素系统，特别是功能性产物血管紧张素II（Ang II）和血管紧张素-（1-7）的表达。现在，这个参与血压控制的关键系统的调节必须涵盖ACE和ACE-2活性之间的整体关系。
