The Department of Cardio-thoracic Surgery, Hunan Children's Hospital, Changsha 410007, China.
Guangxi Key Laboratory of Diabetic Systems Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin 541100, China.
Acta Biochim Biophys Sin (Shanghai). 2021 Mar 2;53(3):273-282. doi: 10.1093/abbs/gmaa176.
The coronavirus disease-2019 (COVID-19) caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly developed into a global pneumonia pandemic. Cardiovascular disease is the major comorbidity of COVID-19 patients and is closely related to the severity of COVID-19. SARS-CoV-2 infection can directly or indirectly cause a series of cardiac complications, including acute myocardial injury and myocarditis, heart failure and cardiac arrest, arrhythmia, acute myocardial infarction, cardiogenic shock, Takotsubo cardiomyopathy, and coagulation abnormalities. Intensive research on the SARS-CoV-2-associated cardiovascular complications is urgently needed to elucidate its exact mechanism and to identify potential drug targets, which will help to formulate effective prevention and treatment strategies. Hence, this review will summarize recent progress regarding the effects of COVID-19 on the cardiovascular system and describe the underlying mechanism of cardiovascular injury caused by SARS-CoV-2.
由新型冠状病毒严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）迅速发展为全球肺炎大流行。心血管疾病是 COVID-19 患者的主要合并症，与 COVID-19 的严重程度密切相关。SARS-CoV-2 感染可直接或间接引起一系列心脏并发症，包括急性心肌损伤和心肌炎、心力衰竭和心搏骤停、心律失常、急性心肌梗死、心源性休克、心尖球囊综合征和凝血异常。迫切需要对 SARS-CoV-2 相关心血管并发症进行深入研究，以阐明其确切机制并确定潜在的药物靶点，这将有助于制定有效的预防和治疗策略。因此，本综述将总结 COVID-19 对心血管系统的影响，并描述 SARS-CoV-2 引起心血管损伤的潜在机制。
