Ascoli M, Liddle R A, Puett D
Mol Cell Endocrinol. 1975 Jul;3(1):21-36. doi: 10.1016/0303-7207(75)90029-5.
The kinetics of plasma clearance, tissue uptake, and urinary excretion of tritiated ovine pituitary luteinizing hormone in adult male rats are reported. Most of the intravenously injected tritiated gonadotropin is cleared from circulation with a half-life of five minutes, and this is independent of the injected amount of hormone over a wide dose range. It was found that the hormone is rapidly removed from circulation by the kidneys, probably by glomerular filtration, and excreted in the urine. The radioactivity present in the urine is associated with material of the same molecular size as the native hormone and, moreover, the urinary hormone retains a significant amount of biological activity. A small amount of the hormone is catabolized by the kidney and liver, and our data suggest that this occurs in the cortex and hepatocytes, respectively.
本文报道了成年雄性大鼠体内氚标记的绵羊垂体促黄体生成素的血浆清除动力学、组织摄取和尿排泄情况。静脉注射的大部分氚标记促性腺激素在5分钟的半衰期内从循环中清除，且在很宽的剂量范围内，这与激素的注射量无关。研究发现，该激素可能通过肾小球滤过作用被肾脏迅速从循环中清除并排泄到尿液中。尿液中的放射性与天然激素分子大小相同的物质相关，此外，尿中的激素保留了大量生物活性。少量激素被肾脏和肝脏分解代谢，我们的数据表明这分别发生在肾皮质和肝细胞中。
