前列腺癌易感性是由紫外线辐射暴露与维生素D受体基因5'单倍型区域多态性之间的相互作用介导的。
Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
作者信息
Rukin Nicholas J, Luscombe Christopher, Moon Sam, Bodiwala Dhaval, Liu Samson, Saxby Mark F, Fryer Anthony A, Alldersea Julie, Hoban Paul R, Strange Richard C
机构信息
Human Disease and Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire ST4 7PX, United Kingdom.
出版信息
Cancer Lett. 2007 Mar 18;247(2):328-35. doi: 10.1016/j.canlet.2006.05.012. Epub 2006 Jul 3.
Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight.
维生素D受体（VDR）基因多态性是前列腺癌风险的候选因素。我们确定单倍型块亚区域C2（单核苷酸多态性C2-1、G/C(3436)、C2-2、A/G(3944)）或C1（C1-1、C/T(20965)、C1-2、C/T(30056)）中的单核苷酸多态性（SNP）是否以紫外线辐射（UVR）依赖的方式与风险相关。在暴露水平极低的男性中，两个亚区域的SNP均与风险相关。单倍型块C中的各种单倍型，包括G(3436)-A(3944)-C(20965)-C(30056)、(G或C)-A-C-C和G-A-(C或T)-C，均与风险增加显著相关（优势比在1.95至2.37之间）。这些发现表明，各种C块SNP通过涉及阳光暴露的机制与前列腺癌风险相关。
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