维生素D受体基因多态性与多发性硬化症患者残疾程度降低有关。
Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis.
作者信息
Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban P R, Rukin N, Alldersea J, Strange R C, Hawkins C P
机构信息
Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK.
出版信息
Mult Scler. 2008 Nov;14(9):1280-3. doi: 10.1177/1352458508094643. Epub 2008 Jul 24.
Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G(1229), C/G(3444), G/A(3944), CC(20965), CC(30056), F/f(30875), C/T(48200), T/t(65013)) with outcome or disability. ff(30875) frequency was lower in cases with EDSS > or = 6.0 than with scores < 6.0 (odds ratio = 0.38, 95% CI = 0.20-0.70). The association of ff(30875) with outcome was not mediated by cumulative exposure to UVR as assessed by questionnaire; low exposure (odds ratio = 0.42, 95% CI = 0.14-1.34) and high exposure (odds ratio = 0.34, 95% CI = 0.16-0.73).
紫外线辐射（UVR）可能通过一种涉及维生素D和维生素D受体（VDR）的机制影响多发性硬化症（MS）的病情转归。在512例病程达10年及以上的MS患者中，我们研究了VDR单核苷酸多态性（A/G(1229)、C/G(3444)、G/A(3944)、CC(20965)、CC(30056)、F/f(30875)、C/T(48200)、T/t(65013)）与病情转归或残疾的关联。扩展残疾状态量表（EDSS）评分≥6.0的患者中ff(30875)的频率低于评分<6.0的患者（比值比=0.38，95%置信区间=0.20 - 0.70）。ff(30875)与病情转归的关联并非由问卷调查评估的UVR累积暴露介导；低暴露组（比值比=0.42，95%置信区间=0.14 - 1.34）和高暴露组（比值比=0.34，95%置信区间=0.16 - 0.73）。
Zotero 插件