Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
Int J Endocrinol. 2010;2010:879362. doi: 10.1155/2010/879362. Epub 2009 Nov 5.
Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency. RXRA polymorphisms, located 3' of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, while RXRA polymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods. Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake.
通过与高亲和力维生素 D 受体 (VDR) 结合，维生素 D 与视黄醇 X 受体 (RXR) 形成异二聚体复合物。已经表明，这两种基因的变异均可改变肾细胞癌 (RCC) 的风险。因此，我们研究了 VDR 和 RXRA 多态性是否会改变维生素 D 和富含钙的食物的摄入频率以及职业性紫外线暴露与中欧地区 777 例 RCC 病例和 1035 例对照者之间的 RCC 风险之间的关联。在该人群中，观察到酸奶摄入频率的增加与 RCC 风险之间呈正相关，而鸡蛋摄入频率的降低则与 RCC 风险呈负相关。位于编码序列 3'端的 RXRA 多态性改变了特定富含维生素 D 的食物与 RCC 风险之间的关联，而位于内含子 1 和 4 中的 RXRA 多态性则改变了特定富含钙的食物与 RCC 风险之间的关联。结果表明，RXRA 基因的变异体改变了观察到的 RCC 风险与钙和维生素 D 摄入之间的关联。
