Bossa R, Chiericozzi M, Efstathiu G, Galatulas I, Ninci M A
Dipartimentro di Farmacologia, Chemioterapia e Tossicologia Medica Emilio Trabucchi, Università di Milano, Italy.
In Vivo. 1991 Jan-Feb;5(1):57-9.
We have reported that the H2 receptor antagonists, cimetidine and ranitidine, interfere with neuromuscular transmission on the isolated phrenic nerve--diaphragm preparation of the rat in vitro and we have suggested that the neuromuscular blockade produced could be ascribed to an action at presynaptic level by competing calcium ions unrelated to their specific effects on H2 histamine receptor: in fact, neuromuscular blockade was reversed by calcium and 4-aminopyridine but not by neostigmine or dimaprit. In the present study these results are confirmed in vivo on the sciatic nerve-gastrocnemius muscle preparation of the rat.
我们曾报道，H2受体拮抗剂西咪替丁和雷尼替丁在体外可干扰大鼠离体膈神经-膈肌标本的神经肌肉传递，并且我们曾提出，所产生的神经肌肉阻滞可能归因于在突触前水平的作用，即通过与钙离子竞争，这与其对H2组胺受体的特异性作用无关：事实上，神经肌肉阻滞可被钙和4-氨基吡啶逆转，但不能被新斯的明或二甲双胍逆转。在本研究中，这些结果在大鼠坐骨神经-腓肠肌标本上得到了体内实验的证实。
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